RG-239 hydrate

• 产品号: R0783
• 分子式: C33H54O4
• 分子量: 514.77946
• 纯 度: ≥98% (HPLC)

产品别名

• 标题: RG-239 hydrate
• IUPAC标准名: (1R,2R,5S,8R,9R,10R,13R,14R,17R,19R)-17-hydroxy-1,2,14,18,18-pentamethyl-8-(prop-1-en-2-yl)-17-(prop-2-en-1-yl)pentacyclo[11.8.0.0^2,^1^0.0^5,^9.0^1^4,^1^9]henicosane-5-carboxylic acid hydrate
• IUPAC传统名: (1R,2R,5S,8R,9R,10R,13R,14R,17R,19R)-17-hydroxy-1,2,14,18,18-pentamethyl-8-(prop-1-en-2-yl)-17-(prop-2-en-1-yl)pentacyclo[11.8.0.0^2,^1^0.0^5,^9.0^1^4,^1^9]henicosane-5-carboxylic acid hydrate
• 别名: 18 dia 2; (3R)-3-Allyl-3-hydroxylup-20(29)-en-28-oic acid hydrate; (3?)-3-Hydroxy-3-(2-propen-1-yl)-lup-20(29)-en-28-oic acid hydrate

产品登记号

• MDL号: MFCD17215967

产品性质

• Empirical Formula (Hill Notation): C33H52O3 · xH2O
• 纯度: ≥98% (HPLC)
• 外观: solid
• 溶解度: DMSO: ≥10 mg/mL
• GHS警示词: Danger
• GHS危险声明: H301
• 欧盟危险性物质标志: 有害性(Harmful) (Xn)
• GHS警示性声明: P301 + P310
• 危险公开号: 22
• 保存温度: 2-8°C
• 德国WGK号: 3

产品详细信息

详细说明 (English)

Biochem/physiol Actions
RG-239 is a TGR5 agonist
Semisynthetic derivative of betulinic acid (3β-allylbetulinic acid), RG-239 is an agonist at the G-protein coupled receptor TGR5. TGR5 signalling induces glucagon-like peptide-1 (GLP-1) release in brown adipose tissue, enhancing glucose tolerance and attenuating diet-induced obesity.

详细说明 (简体中文)

Biochem/physiol Actions
RG-239 is a TGR5 agonist
Semisynthetic derivative of betulinic acid (3β-allylbetulinic acid), RG-239 is an agonist at the G-protein coupled receptor TGR5. TGR5 signalling induces glucagon-like peptide-1 (GLP-1) release in brown adipose tissue, enhancing glucose tolerance and attenuating diet-induced obesity.