JK184

• 产品号: J4205
• CAS号: 315703-52-7
• 分子式: C20H19N3OS
• 分子量: 349.44936
• 纯 度: ≥98% (HPLC)

产品别名

• 标题: JK184
• IUPAC标准名: 2-[(4-ethoxyphenyl)methyl]-4-{2-methylimidazo[1,2-a]pyridin-3-yl}-1,3-thiazole
• IUPAC传统名: 2-[(4-ethoxyphenyl)methyl]-4-{2-methylimidazo[1,2-a]pyridin-3-yl}-1,3-thiazole
• 别名: N-(4-ethoxyphenyl)-4-(2-methylimidazo[1,2-a]pyridin-3-yl)-2-thiazolamine

产品登记号

• CAS号: 315703-52-7

产品性质

• Empirical Formula (Hill Notation): C19H18N4OS
• 纯度: ≥98% (HPLC)
• 外观: off-white to light brown powder
• 溶解度: DMSO: ≥20 mg/mL
• GHS警示词: Danger
• GHS危险声明: H302-H318
• 欧盟危险性物质标志: 有害性(Harmful) (Xn)
• GHS警示性声明: P280-P305 + P351 + P338
• 危险公开号: 22-41
• 安全公开号: 26-36
• 保存温度: room temp
• 德国WGK号: 3

产品详细信息

详细说明 (English)

Biochem/physiol Actions
JK184 is a Hedgehog signaling pathway antagonist. JK184 blocks sonic hedgehog induced Gli transcription with an IC50 of 30 nM, and disrupts hedgehog signalling by inhibition of alcohol dehydrogenase 7 and depolymerization of mirotubules.

详细说明 (简体中文)

Biochem/physiol Actions
JK184 is a Hedgehog signaling pathway antagonist. JK184 blocks sonic hedgehog induced Gli transcription with an IC50 of 30 nM, and disrupts hedgehog signalling by inhibition of alcohol dehydrogenase 7 and depolymerization of mirotubules.