PS48

• 产品号: P0022
• CAS号: 1180676-32-7
• 分子式: C17H15ClO2
• 分子量: 286.7528
• 纯 度: ≥98% (HPLC)
• 保 存: protect from light

产品别名

• 标题: PS48
• IUPAC标准名: 5-(4-chlorophenyl)-3-phenylpent-2-enoic acid
• IUPAC传统名: 5-(4-chlorophenyl)-3-phenylpent-2-enoic acid
• 别名: 5-(4-Chloro-phenyl)-3-phenyl-pent-2-enoic acid

产品登记号

• MDL号: MFCD17215962
• CAS号: 1180676-32-7

产品性质

• Empirical Formula (Hill Notation): C17H15ClO2
• 纯度: ≥98% (HPLC)
• 外观: white to off-white powder
• 溶解度: DMSO: >20 mg/mL
• RID/ADR: UN 3077 9/PG 3
• 保存条件: protect from light
• 保存温度: 2-8°C
• 联合国危险货物等级: 9
• 联合国危险货物编号: 3077
• 联合国危险货物包装类别(PG): 3
• 德国WGK号: 3

产品详细信息

详细说明 (English)

Biochem/physiol Actions
PS48 is a PDK1 (phosphoinositide-dependent protein kinase 1) activator which binds to the HM/PIF binding pocket rather than the ATP-binding site. PS48 is one of only a few truly allosteric compounds targeting a regulatory binding site on a protein kinase catalytic domain that is not adjacent to or overlapping with the ATP-binding site.

详细说明 (简体中文)

Biochem/physiol Actions
PS48 is a PDK1 (phosphoinositide-dependent protein kinase 1) activator which binds to the HM/PIF binding pocket rather than the ATP-binding site. PS48 is one of only a few truly allosteric compounds targeting a regulatory binding site on a protein kinase catalytic domain that is not adjacent to or overlapping with the ATP-binding site.