Proguanil hydrochloride

• 产品号: G7048
• CAS号: 637-32-1
• 分子式: C11H17Cl2N5
• 分子量: 290.19218
• 纯 度: ≥95% (HPLC)
• 保 存: desiccated

产品别名

• 标题: Proguanil hydrochloride
• IUPAC标准名: 1-3-(4-chlorophenyl)carbamimidamido-N-(propan-2-yl)methanimidamide hydrochloride
• IUPAC传统名: proguanil hydrochloride
• 别名: N1-(4-Chlorophenyl)-N5-isopropylbiguanide; Chlorguanide

产品登记号

• CAS号: 637-32-1
• EC号: 211-283-7
• MDL号: MFCD01732193

产品性质

• Empirical Formula (Hill Notation): C11H16ClN5·HCl
• 纯度: ≥95% (HPLC)
• 外观: solid
• 溶解度: acetonitrile: water: ~1 mg/mL (60/40)
• GHS警示词: Danger
• GHS危险声明: H301
• 欧盟危险性物质标志: 有毒(Toxic) (T)
• GHS警示性声明: P301 + P310
• RID/ADR: UN 2811 6.1/PG 3
• 危险公开号: 25
• RTECS编号: DU1750000
• 安全公开号: 45
• 保存条件: desiccated
• 保存温度: 2-8°C
• 联合国危险货物等级: 6.1
• 联合国危险货物编号: 2811
• 联合国危险货物包装类别(PG): 3
• 德国WGK号: 3

产品详细信息

详细说明 (English)

Biochem/physiol Actions
Chlorguanide (proguanil) is combined with atovaquone for malaria prophylaxis. The two compounds act synergistically to inhibit the plasmodial dihydrofolate reductase (DHFR) and interrupt the electron transport chain.1 Mutations in DHFR account for the development of resistant strains.2

详细说明 (简体中文)

Biochem/physiol Actions
Chlorguanide (proguanil) is combined with atovaquone for malaria prophylaxis. The two compounds act synergistically to inhibit the plasmodial dihydrofolate reductase (DHFR) and interrupt the electron transport chain.1 Mutations in DHFR account for the development of resistant strains.2