SJ-172550

• 产品号: S7451
• CAS号: 431979-47-4
• 分子式: C22H21ClN2O5
• 分子量: 428.86554
• 纯 度: ≥98% (HPLC)

产品别名

• 标题: SJ-172550
• IUPAC标准名: methyl 2-{2-chloro-6-ethoxy-4-[(3-methyl-5-oxo-1-phenyl-4,5-dihydro-1H-pyrazol-4-ylidene)methyl]phenoxy}acetate
• IUPAC传统名: methyl 2-{2-chloro-6-ethoxy-4-[(3-methyl-5-oxo-1-phenylpyrazol-4-ylidene)methyl]phenoxy}acetate
• 别名: 2-[2-Chloro-4-[(1,5-dihydro-3-methyl-5-oxo-1-phenyl-4H-pyrazol-4-ylidene)methyl]-6-ethoxyphenoxy]-acetic acid methyl ester

产品登记号

• CAS号: 431979-47-4
• MDL号: MFCD03142926

产品性质

• Empirical Formula (Hill Notation): C22H21N2O5Cl
• 纯度: ≥98% (HPLC)
• 外观: orange powder
• 溶解度: DMSO: ≥30 mg/mL
• GHS警示词: Warning
• GHS危险声明: H302
• 欧盟危险性物质标志: 有害性(Harmful) (Xn)
• 危险公开号: 22
• 保存温度: 2-8°C
• 德国WGK号: 3

产品详细信息

详细说明 (English)

Biochem/physiol Actions
SJ-17255 is a MDMX inhibitor. Similarly to MDM2, MDMX regulates p53. But in contrast to MDM2, MDMX appears to directly regulate p53 transcription. SJ-172550 is a first small-molecule inhibitor of MDMX with a low micromolar binding constant. It appears that SJ-172550 is binding to the p53-binding pocket of MDMX, thus liberating p53 to induce apoptosis.

详细说明 (简体中文)

Biochem/physiol Actions
SJ-17255 is a MDMX inhibitor. Similarly to MDM2, MDMX regulates p53. But in contrast to MDM2, MDMX appears to directly regulate p53 transcription. SJ-172550 is a first small-molecule inhibitor of MDMX with a low micromolar binding constant. It appears that SJ-172550 is binding to the p53-binding pocket of MDMX, thus liberating p53 to induce apoptosis.