PD 0325901

• 产品号: PZ0162
• CAS号: 391210-10-9
• 分子式: C16H14F3IN2O4
• 分子量: 482.1930396
• 纯 度: ≥98% (HPLC)

产品别名

• 标题: PD 0325901
• IUPAC标准名: N-[(2R)-2,3-dihydroxypropoxy]-3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]benzamide
• IUPAC传统名: N-[(2R)-2,3-dihydroxypropoxy]-3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]benzamide
• 别名: N-[(2R)-2,3-Dihydroxypropoxy]-3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]-benzamide

产品登记号

• MDL号: MFCD08435926
• CAS号: 391210-10-9

产品性质

• Empirical Formula (Hill Notation): C16H14F3IN2O4
• 纯度: ≥98% (HPLC)
• 外观: white to off-white powder
• 比旋光度: [α]/D -1.8 to -3.0°, c = 1 mg/mL in methanol
• 溶解度: DMSO: ≥20 mg/mL
• GHS警示词: Danger
• GHS危险声明: H301-H373-H410
• 欧盟危险性物质标志: 有毒(Toxic) (T)
• 欧盟危险性物质标志: 环境危害性(Nature polluting) (N)
• GHS警示性声明: P273-P301 + P310-P501
• 危险公开号: 25-48-50
• 安全公开号: 22-36/37/39-61
• 保存温度: 2-8°C
• 德国WGK号: 3

产品详细信息

详细说明 (English)

Legal Information
Sold for research purposes under agreement from Pfizer Inc.
Biochem/physiol Actions
PD 0325901 is a potent MKK1 (MEK1) and MKK2 (MEK2) inhibitor. The Ki is 1.1 and 0.79 nM for MEK1 and MEK2, respectively. PD 0325901 was inactive against a panel of 27 other kinases. PD 0325901 inhibited C26 tumor pERK by 75% when dosed at 25 mg/kg in mice.

详细说明 (简体中文)

Legal Information
Sold for research purposes under agreement from Pfizer Inc.
Biochem/physiol Actions
PD 0325901 is a potent MKK1 (MEK1) and MKK2 (MEK2) inhibitor. The Ki is 1.1 and 0.79 nM for MEK1 and MEK2, respectively. PD 0325901 was inactive against a panel of 27 other kinases. PD 0325901 inhibited C26 tumor pERK by 75% when dosed at 25 mg/kg in mice.