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Myxothiazol

产品号 T5580 公司名称 Sigma Aldrich
CAS号 76706-55-3 公司网站 http://www.sigmaaldrich.com
分子式 C25H33N3O3S2 电 话 1-800-521-8956
分子量 487.67782 传 真
纯 度 ≥98% (HPLC) 电子邮件
保 存 protect from light Chembase数据库ID: 154721

产品价格信息

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产品别名

标题
Myxothiazol
IUPAC标准名
(4R,5S)-3,5-dimethoxy-4-methyl-7-(2-{2-[(2S)-7-methylocta-3,5-dien-2-yl]-1,3-thiazol-4-yl}-1,3-thiazol-4-yl)hepta-2,6-dienamide
IUPAC传统名
(4R,5S)-3,5-dimethoxy-4-methyl-7-(2-{2-[(2S)-7-methylocta-3,5-dien-2-yl]-1,3-thiazol-4-yl}-1,3-thiazol-4-yl)hepta-2,6-dienamide

产品登记号

MDL号 MFCD00043397
CAS号 76706-55-3

产品性质

生物来源 from Myxococcus fulvus Mx f85
Empirical Formula (Hill Notation) C25H33N3O3S2
纯度 ≥98% (HPLC)
溶解度 DMSO: soluble
溶解度 acetone: soluble
溶解度 chloroform: soluble
溶解度 dichloromethane: soluble
溶解度 ethanol: soluble
溶解度 ethyl acetate: soluble
溶解度 methanol: soluble
GHS危险品标识 GHS06
GHS警示词 Danger
GHS危险声明 H300
欧盟危险性物质标志 剧毒(Highly toxic) 剧毒(Highly toxic) (T+)
MSDS下载 下载链接
GHS警示性声明 P264-P301 + P310
危险公开号 28
安全公开号 28-36/37-45
保存条件 protect from light
保存条件 under inert gas
保存温度 -20°C
德国WGK号 3

产品详细信息

详细说明 (English)
Biochem/physiol Actions
Myxothiazol, an antibiotic with activity against fungi and insects, is a strong inhibitor of mitochondrial cytochrome b/c1-segment of respiratory chain.1 Myxothiazol binds to the quinol oxidation (Qo) site of the bc1 complex, blocking electron transfer to the Rieske iron-sulfur protein in the mitochondrial respiratory chain.2,3 Oxygen consumption blockage leads to a cytostatic effect that could be reversed. Myxothiazol, as other Epothilones, which are known for their anti tumor activity, contains a thiazole ring that is formed by the incorporation of cysteine into the polyketide backbone.4
详细说明 (简体中文)
Biochem/physiol Actions
Myxothiazol, an antibiotic with activity against fungi and insects, is a strong inhibitor of mitochondrial cytochrome b/c1-segment of respiratory chain.1 Myxothiazol binds to the quinol oxidation (Qo) site of the bc1 complex, blocking electron transfer to the Rieske iron-sulfur protein in the mitochondrial respiratory chain.2,3 Oxygen consumption blockage leads to a cytostatic effect that could be reversed. Myxothiazol, as other Epothilones, which are known for their anti tumor activity, contains a thiazole ring that is formed by the incorporation of cysteine into the polyketide backbone.4

参考文献