VU0357017 monohydrochloride

• 产品号: V4640
• CAS号: 1135242-13-5
• 分子式: C18H28ClN3O3
• 分子量: 369.88622
• 纯 度: ≥98% (HPLC)

产品别名

• 标题: VU0357017 monohydrochloride
• IUPAC标准名: ethyl 4-({2-[(2-methylphenyl)formamido]ethyl}amino)piperidine-1-carboxylate hydrochloride
• IUPAC传统名: ethyl 4-({2-[(2-methylphenyl)formamido]ethyl}amino)piperidine-1-carboxylate hydrochloride
• 别名: CID 25010775; 4-[[2-[(2-Methylbenzoyl)amino]ethyl]amino]-1-piperidinecarboxylic acid ethyl ester monohydrochloride; ML071 hydrochloride; SID 56353039

产品登记号

• MDL号: MFCD17215959
• CAS号: 1135242-13-5

产品性质

• Empirical Formula (Hill Notation): C18H27N3O3 · HCl
• 纯度: ≥98% (HPLC)
• 外观: white to off-white powder
• 溶解度: DMSO: ≥10 mg/mL
• 欧盟危险性物质标志: 环境危害性(Nature polluting) (N)
• 危险公开号: 52/53
• 安全公开号: 61
• 保存温度: 2-8°C
• 德国WGK号: 2

产品详细信息

详细说明 (English)

Biochem/physiol Actions
VU0357017 is a subtype-selective M1 muscarinic acetylcholine allosteric agonist. VU0357017 has a potency of 200 nM and Achmax of 81% and had no activity at M2-M5 up to the highest concentrations tested and also had little or no detectable antagonist activity at any other mAChR subtype at concentrations over 2 orders of magnitude higher than those required to activate M1 or activity at a large panel of GPCRs, ion channels, and transporters. In contrast, TBPB inhibited responses to ACh at each of the other mAChR subtypes. VU0357017 was active in reversing cognitive deficits induced by scopolamine in a preclinical rodent model.

详细说明 (简体中文)

Biochem/physiol Actions
VU0357017 is a subtype-selective M1 muscarinic acetylcholine allosteric agonist. VU0357017 has a potency of 200 nM and Achmax of 81% and had no activity at M2-M5 up to the highest concentrations tested and also had little or no detectable antagonist activity at any other mAChR subtype at concentrations over 2 orders of magnitude higher than those required to activate M1 or activity at a large panel of GPCRs, ion channels, and transporters. In contrast, TBPB inhibited responses to ACh at each of the other mAChR subtypes. VU0357017 was active in reversing cognitive deficits induced by scopolamine in a preclinical rodent model.