7,8-Dihydroxyflavone hydrate

• 产品号: D5446
• CAS号: 38183-03-8(anhydrous)
• 分子式: C15H10O4
• 分子量: 254.2375
• 纯 度: ≥98% (HPLC)
• 保 存: desiccated

产品别名

• 标题: 7,8-Dihydroxyflavone hydrate
• IUPAC标准名: 7,8-dihydroxy-2-phenyl-4H-chromen-4-one
• IUPAC传统名: 7,8-dihydroxy-2-phenylchromen-4-one

产品登记号

• MDL号: MFCD00006836
• EC号: 253-812-4
• CAS号: 38183-03-8(anhydrous)

产品性质

• Empirical Formula (Hill Notation): C15H10O4 · xH2O
• 纯度: ≥98% (HPLC)
• 外观: solid
• 溶解度: DMSO: soluble24 mg/mL
• GHS警示词: Warning
• GHS危险声明: H302
• 欧盟危险性物质标志: 有害性(Harmful) (Xn)
• 危险公开号: 22
• RTECS编号: DJ3004000
• 保存条件: desiccated
• 保存温度: room temp
• 德国WGK号: 3

产品详细信息

详细说明 (English)

Biochem/physiol Actions
7,8-Dihydroxyflavone is a selective tyrosine kinase receptor B (TrkB) receptor agonist. It manifests all the therapeutic effects of brain-derived neurotrophic factor (BDNF)-such as protecting neurons from apoptosis, inhibiting kainic acid-induced toxicity, decreasing infarct volumes in stroke, and neuroprotecting in an animal model of Parkinson′s disease-without the poor pharmacokinetic profile of BDNF limiting its therapeutic potential.1
Other Notes
Tandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. D5446.pdf Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To learn more, visit sigma.com/metlin.

详细说明 (简体中文)

Biochem/physiol Actions
7,8-Dihydroxyflavone is a selective tyrosine kinase receptor B (TrkB) receptor agonist. It manifests all the therapeutic effects of brain-derived neurotrophic factor (BDNF)-such as protecting neurons from apoptosis, inhibiting kainic acid-induced toxicity, decreasing infarct volumes in stroke, and neuroprotecting in an animal model of Parkinson′s disease-without the poor pharmacokinetic profile of BDNF limiting its therapeutic potential.1
Other Notes
Tandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. D5446.pdf Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To learn more, visit sigma.com/metlin.