5Z-7-Oxozeaenol

• 产品号: O9890
• CAS号: 253863-19-3
• 分子式: C19H22O7
• 分子量: 362.37378
• 纯 度: ≥98% (HPLC)

产品别名

• 标题: 5Z-7-Oxozeaenol
• IUPAC标准名: (3S,8S,9S)-8,9,16-trihydroxy-14-methoxy-3-methyl-3,4,7,8,9,10-hexahydro-1H-2-benzoxacyclotetradecine-1,7-dione
• IUPAC传统名: (3S,8S,9S)-8,9,16-trihydroxy-14-methoxy-3-methyl-4,8,9,10-tetrahydro-3H-2-benzoxacyclotetradecine-1,7-dione
• 别名: FR148083; C 292; L 783279; F 152; LL-Z1640-2

产品登记号

• MDL号: MFCD12912700
• CAS号: 253863-19-3

产品性质

• Empirical Formula (Hill Notation): C19H22O7
• 纯度: ≥98% (HPLC)
• 外观: white to off-white powder
• 溶解度: DMSO: >10 mg/mL
• GHS警示词: Danger
• GHS危险声明: H301
• 欧盟危险性物质标志: 有毒(Toxic) (T)
• GHS警示性声明: P301 + P310
• RID/ADR: UN 2811 6.1/PG 3
• 危险公开号: 25
• 安全公开号: 45
• 保存温度: 2-8°C
• 联合国危险货物等级: 6.1
• 联合国危险货物编号: 2811
• 联合国危险货物包装类别(PG): 3
• 德国WGK号: 3

产品详细信息

详细说明 (English)

Biochem/physiol Actions
5Z-7-oxozeaenol is a potent ATP-competitive irreversible inhibitor of ERK2 (IC50= 80 nM), TAK1 (MKK7), and MEK1, which all contain a common cysteine residue in the ATP-binding site. It has no activity against other MAP kinases. 5Z-7-oxozeaenol is also anti-inflammatory.

详细说明 (简体中文)

Biochem/physiol Actions
5Z-7-oxozeaenol is a potent ATP-competitive irreversible inhibitor of ERK2 (IC50= 80 nM), TAK1 (MKK7), and MEK1, which all contain a common cysteine residue in the ATP-binding site. It has no activity against other MAP kinases. 5Z-7-oxozeaenol is also anti-inflammatory.