Ro 60-0175

• 产品号: R0408
• 分子式: C15H16ClFN2O4
• 分子量: 342.7499432
• 纯 度: ≥99% (HPLC)

产品别名

• 标题: Ro 60-0175
• IUPAC标准名: (2S)-1-(6-chloro-5-fluoro-1H-indol-1-yl)propan-2-amine; but-2-enedioic acid
• IUPAC传统名: (2S)-1-(6-chloro-5-fluoroindol-1-yl)propan-2-amine; butenedioic acid
• 别名: (aS)-6-Chloro-5-fluoro-a-methyl-1H-indole-1-ethanamine monofumarate

产品登记号

• MDL号: MFCD06798313

产品性质

• Empirical Formula (Hill Notation): C11H12ClFN2 ·C4H4O4
• 纯度: ≥99% (HPLC)
• 外观: solid
• 溶解度: deionized water: soluble10 mg/mL
• GHS警示词: Warning
• GHS危险声明: H315-H319
• 欧盟危险性物质标志: 刺激性(Irritant) (Xi)
• GHS警示性声明: P305 + P351 + P338
• 危险公开号: 36/37/38
• 安全公开号: 26
• 保存温度: 2-8°C
• 德国WGK号: 3

产品详细信息

详细说明 (English)

Biochem/physiol Actions
Ro 60-0175 was originally reported to be a potent, selective 5-HT2C receptor agonist (with pKi values of 9, 7.5, 5.4, 5.2 and 5.6 for human 5-HT2C, 2A, 1A, 6 and 7 receptors respectively). That assignment has been questioned, however, supported by evidence from coadministration of Ro 60-0175 and SB 242084, a selective 5-HT2C antagonist.1

详细说明 (简体中文)

Biochem/physiol Actions
Ro 60-0175 was originally reported to be a potent, selective 5-HT2C receptor agonist (with pKi values of 9, 7.5, 5.4, 5.2 and 5.6 for human 5-HT2C, 2A, 1A, 6 and 7 receptors respectively). That assignment has been questioned, however, supported by evidence from coadministration of Ro 60-0175 and SB 242084, a selective 5-HT2C antagonist.1