Cryptotanshinone

• 产品号: C5624
• CAS号: 35825-57-1
• 分子式: C19H20O3
• 分子量: 296.3603
• 纯 度: ≥98% (HPLC)
• 保 存: desiccated

产品别名

• 标题: Cryptotanshinone
• IUPAC标准名: (14R)-6,6,14-trimethyl-12-oxatetracyclo[8.7.0.0^2,^7.0^1^1,^1^5]heptadeca-1(10),2(7),8,11(15)-tetraene-16,17-dione
• IUPAC传统名: (14R)-6,6,14-trimethyl-12-oxatetracyclo[8.7.0.0^2,^7.0^1^1,^1^5]heptadeca-1(10),2(7),8,11(15)-tetraene-16,17-dione
• 别名: 1,2,6,7,8,9-hexahydro-1,6,6-trimethyl- (R)-phenanthro(1,2-b)furan-10,11-dione; Cryptotanshinon; Tanshinone c

产品登记号

• MDL号: MFCD07636810
• CAS号: 35825-57-1

产品性质

• GHS警示性声明: P273-P301 + P310-P501
• RID/ADR: UN 2811 6.1/PG 3
• 危险公开号: 25-50/53
• 安全公开号: 45-60-61
• 保存条件: desiccated
• 保存条件: protect from light
• 保存温度: 2-8°C
• 联合国危险货物等级: 6.1
• 联合国危险货物编号: 2811
• 联合国危险货物包装类别(PG): 3
• 德国WGK号: 3
• GHS警示词: Danger
• GHS危险声明: H301-H410
• 欧盟危险性物质标志: 有毒(Toxic) (T)
• 欧盟危险性物质标志: 环境危害性(Nature polluting) (N)
• Empirical Formula (Hill Notation): C19H20O3
• 纯度: ≥98% (HPLC)
• 外观: orange-brown powder
• 溶解度: DMSO: ≥5 mg/mL

产品详细信息

详细说明 (简体中文)

Biochem/physiol Actions
Cryptotanshinone is a quinoid diterpene isolated from the root of the Asian medicinal plant, Salvia miotiorrhiza bunge. Recently it was discovered that the compound is a potent STAT3 inhibitor. Cryptotanshinone rapidly inhibited STAT3 Tyr705 phosphorylation through a JAK2-independent mechanism. Cryptotanshinone selectively inhibits STAT3-activated cell lines through binding to monomer STAT3, subsequently blocking the dimerization and inhibiting STAT3 transcriptional regulatory activity. Previously, it was reported that the compound counteracts inflammation through the inhibition of cyclooxygenase II activity and endothelin-1 expression. In traditional oriental medicine dried roots of Salvia Miltiorrhiza Bunge (Danshen) have commonly been used for the treatment of circulatory disorders, liver disease, coronary heart disease, hepatitis, and chronic renal failure.

详细说明 (English)

Biochem/physiol Actions
Cryptotanshinone is a quinoid diterpene isolated from the root of the Asian medicinal plant, Salvia miotiorrhiza bunge. Recently it was discovered that the compound is a potent STAT3 inhibitor. Cryptotanshinone rapidly inhibited STAT3 Tyr705 phosphorylation through a JAK2-independent mechanism. Cryptotanshinone selectively inhibits STAT3-activated cell lines through binding to monomer STAT3, subsequently blocking the dimerization and inhibiting STAT3 transcriptional regulatory activity. Previously, it was reported that the compound counteracts inflammation through the inhibition of cyclooxygenase II activity and endothelin-1 expression. In traditional oriental medicine dried roots of Salvia Miltiorrhiza Bunge (Danshen) have commonly been used for the treatment of circulatory disorders, liver disease, coronary heart disease, hepatitis, and chronic renal failure.