PMEG hydrate

• 产品号: M2199
• 分子式: C8H14N5O6P
• 分子量: 307.200421
• 纯 度: ≥98% (HPLC)
• 保 存: desiccated

产品别名

• 标题: PMEG hydrate
• IUPAC标准名: {[2-(2-amino-6-oxo-6,9-dihydro-1H-purin-9-yl)ethoxy]methyl}phosphonic acid hydrate
• IUPAC传统名: [2-(2-amino-6-oxo-1H-purin-9-yl)ethoxy]methylphosphonic acid hydrate
• 别名: 9-[2-(Phosphonomethoxy)ethyl]guanine hydrate

产品登记号

• MDL号: MFCD19443863

产品性质

• Empirical Formula (Hill Notation): C8H12N5O5P · xH2O
• 纯度: ≥98% (HPLC)
• 外观: white to off-white powder
• 溶解度: DMSO: ≥5 mg/mL
• GHS警示词: Danger
• GHS危险声明: H300
• 欧盟危险性物质标志: 有毒(Toxic) (T)
• GHS警示性声明: P264-P301 + P310
• 危险公开号: 25
• 安全公开号: 45
• 保存条件: desiccated
• 保存温度: 2-8°C

产品详细信息

详细说明 (English)

Biochem/physiol Actions
The acyclic nucleotide 9-(2-phosphonylmethoxyethyl)guanine (PMEG) forms an active phosphorylated metabolite, PMEG diphosphate (PMEGpp), in cells and causes cytotoxicity in dividing cells due to potent inhibition of the nuclear DNA polymerases resulting in inhibition of DNA synthesis and/or DNA repair.

详细说明 (简体中文)

Biochem/physiol Actions
The acyclic nucleotide 9-(2-phosphonylmethoxyethyl)guanine (PMEG) forms an active phosphorylated metabolite, PMEG diphosphate (PMEGpp), in cells and causes cytotoxicity in dividing cells due to potent inhibition of the nuclear DNA polymerases resulting in inhibition of DNA synthesis and/or DNA repair.