Bisantrene dihydrochloride

• 产品号: B4563
• CAS号: 78186-34-2
• 分子式: C22H24Cl2N8
• 分子量: 471.38556
• 纯 度: ≥98% (HPLC)

产品别名

• 标题: Bisantrene dihydrochloride
• IUPAC标准名: 2-{2-[(10-{[2-(4,5-dihydro-1H-imidazol-2-yl)hydrazin-1-ylidene]methyl}anthracen-9-yl)methylidene]hydrazin-1-yl}-4,5-dihydro-1H-imidazole dihydrochloride
• IUPAC传统名: 2-{2-[(10-{[2-(4,5-dihydro-1H-imidazol-2-yl)hydrazin-1-ylidene]methyl}anthracen-9-yl)methylidene]hydrazin-1-yl}-4,5-dihydro-1H-imidazole dihydrochloride
• 别名: Bis((4,5-dihydro-1H-imidazol-2-yl)hydrazone)-9,10-anthracenedicarboxaldehyde dihydrochloride; NSC 337766

产品登记号

• CAS号: 78186-34-2
• MDL号: MFCD01743164

产品性质

• Empirical Formula (Hill Notation): C22H22N8 ·2HCl
• 纯度: ≥98% (HPLC)
• 外观: solid
• 溶解度: deionized water: soluble8 mg/mL
• GHS警示词: Warning
• GHS危险声明: H302-H400
• 欧盟危险性物质标志: 有害性(Harmful) (Xn)
• 欧盟危险性物质标志: 环境危害性(Nature polluting) (N)
• GHS警示性声明: P273
• RID/ADR: UN 2811 6.1/PG 3
• 危险公开号: 22-50/53
• 安全公开号: 60-61
• 保存温度: room temp
• 联合国危险货物等级: 6.1
• 联合国危险货物编号: 2811
• 联合国危险货物包装类别(PG): 3
• 德国WGK号: 3

产品详细信息

详细说明 (English)

Biochem/physiol Actions
Bisantrene dihydrochloride is an antineoplastic agent, MDR1 substrate, DNA intercalator, and topoisomerase II poison. Cancer cells that develop resistance to bisantrene tend to overexpress P-glycoprotein. Bisantrene can be used to select for P-glycoprotein-mediated multiple drug resistance. The data suggest that bisantrene is an excellent substrate for P-glycoprotein.1

详细说明 (简体中文)

Biochem/physiol Actions
Bisantrene dihydrochloride is an antineoplastic agent, MDR1 substrate, DNA intercalator, and topoisomerase II poison. Cancer cells that develop resistance to bisantrene tend to overexpress P-glycoprotein. Bisantrene can be used to select for P-glycoprotein-mediated multiple drug resistance. The data suggest that bisantrene is an excellent substrate for P-glycoprotein.1