ITX3

• 产品号: I1411
• CAS号: 347323-96-0
• 分子式: C22H25N3OS
• 分子量: 379.5184
• 纯 度: ≥98% (HPLC)

产品别名

• 标题: ITX3
• IUPAC标准名: 4-[(2,5-dimethyl-1-phenyl-1H-pyrrol-3-yl)methylidene]-5-thia-2,7-diazatricyclo[6.4.0.0^2,^6]dodecan-3-one
• IUPAC传统名: 4-[(2,5-dimethyl-1-phenylpyrrol-3-yl)methylidene]-5-thia-2,7-diazatricyclo[6.4.0.0^2,^6]dodecan-3-one
• 别名: 2-[(2,5-Dimethyl-1-phenyl-1H-pyrrol-3-yl)methylene]-thiazolo[3,2-a]benzimidazol-3(2H)-one

产品登记号

• MDL号: MFCD02629172
• CAS号: 347323-96-0

产品性质

• Empirical Formula (Hill Notation): C22H17N3OS
• 纯度: ≥98% (HPLC)
• 外观: powder
• 溶解度: DMSO: ≥4 mg/mL
• 保存温度: room temp
• 德国WGK号: 3

产品详细信息

详细说明 (English)

Biochem/physiol Actions
ITX3 is a specific inhibitor of endogenous TrioN activity acting on the GEF domain and selective cell active inhibitor of the Trio/RhoG/Rac1 pathway. The compound is active in whole cell assay where it inhibits the formation of TrioN-dependent cell structures. ITX3 appears to be specific for TrioN inhibition rather than other RhoGEFs.

详细说明 (简体中文)

Biochem/physiol Actions
ITX3 is a specific inhibitor of endogenous TrioN activity acting on the GEF domain and selective cell active inhibitor of the Trio/RhoG/Rac1 pathway. The compound is active in whole cell assay where it inhibits the formation of TrioN-dependent cell structures. ITX3 appears to be specific for TrioN inhibition rather than other RhoGEFs.