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Hyp9_分子结构_CAS_3118-34-1)
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Hyp9

产品号 H9791 公司名称 Sigma Aldrich
CAS号 3118-34-1 公司网站 http://www.sigmaaldrich.com
分子式 C18H26O5 电 话 1-800-521-8956
分子量 322.39604 传 真
纯 度 ≥98% (HPLC) 电子邮件
保 存 Chembase数据库ID: 154668

产品价格信息

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产品别名

标题
Hyp9
IUPAC标准名
1-(3-hexanoyl-2,4,6-trihydroxyphenyl)hexan-1-one
IUPAC传统名
1-(3-hexanoyl-2,4,6-trihydroxyphenyl)hexan-1-one
别名
1,1′-(2,4,6-Trihydroxy-1,3-phenylene)bis-1-hexanone
2,4-(bis-1-ketohexyl)phloroglucinol

产品登记号

CAS号 3118-34-1
MDL号 MFCD16875422

产品性质

Empirical Formula (Hill Notation) C18H26O5
纯度 ≥98% (HPLC)
外观 white to light yellow powder
溶解度 DMSO: >20 mg/mL
MSDS下载 下载链接
保存温度 2-8°C

产品详细信息

详细说明 (English)
Biochem/physiol Actions
Hyperforin is the active ingredient in St. John′s Wort. It is used to treat depression, known to indirectly inhibit reuptake of serotonin and norepinephrine at the synapse, and recently discovered to exert its actions by directly activating TRPC6. TRPC6 is a member of the canonical transient receptor potential (TRPC) family of ion channels. DAG is the endogenous activator of this channel, and Hyperforin is the only known TRPC6-selective activator. Although it is broadly used, Hyperforin is chemically unstable. Efforts to find a stable but pharmacologically similar TRPC6 activator resulted in the discovery of Hyp9, a simplified phloroglucinol derivative. Like Hyperforin, Hyp9 inhibits serotonin reuptake and induces neurite outgrowth. It increases calcium entry into the cell and selectively increases current through TRPC6 channels.
详细说明 (简体中文)
Biochem/physiol Actions
Hyperforin is the active ingredient in St. John′s Wort. It is used to treat depression, known to indirectly inhibit reuptake of serotonin and norepinephrine at the synapse, and recently discovered to exert its actions by directly activating TRPC6. TRPC6 is a member of the canonical transient receptor potential (TRPC) family of ion channels. DAG is the endogenous activator of this channel, and Hyperforin is the only known TRPC6-selective activator. Although it is broadly used, Hyperforin is chemically unstable. Efforts to find a stable but pharmacologically similar TRPC6 activator resulted in the discovery of Hyp9, a simplified phloroglucinol derivative. Like Hyperforin, Hyp9 inhibits serotonin reuptake and induces neurite outgrowth. It increases calcium entry into the cell and selectively increases current through TRPC6 channels.

参考文献