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SB-271046A

产品号 S5326 公司名称 Sigma Aldrich
CAS号 209481-24-3 公司网站 http://www.sigmaaldrich.com
分子式 C20H23Cl2N3O3S2 电 话 1-800-521-8956
分子量 488.45092 传 真
纯 度 ≥98% (HPLC) 电子邮件
保 存 Chembase数据库ID: 154663

产品价格信息

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产品别名

标题
SB-271046A
IUPAC标准名
5-chloro-N-[4-methoxy-3-(piperazin-1-yl)phenyl]-3-methyl-1-benzothiophene-2-sulfonamide hydrochloride
IUPAC传统名
5-chloro-N-[4-methoxy-3-(piperazin-1-yl)phenyl]-3-methyl-1-benzothiophene-2-sulfonamide hydrochloride
别名
5-Chloro-N-(4-methoxy-3-piperazin-1-yl-phenyl)-3-methyl-2-benzo-thiophenesulfonamide hydrochloride

产品登记号

MDL号 MFCD10565914
CAS号 209481-24-3

产品性质

Empirical Formula (Hill Notation) C20H22ClN3O3S2 · HCl
纯度 ≥98% (HPLC)
外观 powder
溶解度 DMSO: >20 mg/mL
MSDS下载 下载链接
保存温度 2-8°C
德国WGK号 nwg

产品详细信息

详细说明 (English)
Biochem/physiol Actions
The first potent and selective 5-HT6 antagonist. Training in cognitive tasks, as well as administration SB-271046, induces an increase in pERK1/2 and pCREB1 levels, while CREB2 levels are significantly reduced; cognition-enhancing properties of SB-271046 are attributed to the effect on pERK1/2, not pCREB1/2.1 SB-271046 reverses MK-801-induced, but not scopolamine-induced, learning impairments. However, with coadministration of galanthamine, both types of learning impairments were ameliorated.2
详细说明 (简体中文)
Biochem/physiol Actions
The first potent and selective 5-HT6 antagonist. Training in cognitive tasks, as well as administration SB-271046, induces an increase in pERK1/2 and pCREB1 levels, while CREB2 levels are significantly reduced; cognition-enhancing properties of SB-271046 are attributed to the effect on pERK1/2, not pCREB1/2.1 SB-271046 reverses MK-801-induced, but not scopolamine-induced, learning impairments. However, with coadministration of galanthamine, both types of learning impairments were ameliorated.2

参考文献