Pilsicainide hydrochloride

• 产品号: P0026
• 分子式: C17H25ClN2O
• 分子量: 308.8462
• 纯 度: ≥98% (HPLC)

产品别名

• 标题: Pilsicainide hydrochloride
• IUPAC标准名: N-(2,6-dimethylphenyl)-2-(hexahydro-1H-pyrrolizin-7a-yl)acetamide hydrochloride
• IUPAC传统名: pilsicainide hydrochloride
• 别名: Pilzicainide hydrochloride; N-(2,6-Dimethylphenyl)tetrahydro-1H-pyrrolizine-7a(5H)-acetamide hydrochloride; SUN 1165

产品登记号

• MDL号: MFCD00903769

产品性质

• Empirical Formula (Hill Notation): C17H24N2O · xHCl
• 纯度: ≥98% (HPLC)
• 外观: white to beige powder
• 溶解度: deionized water: >5 mg/mL
• GHS警示词: Warning
• GHS危险声明: H302
• 欧盟危险性物质标志: 有害性(Harmful) (Xn)
• RID/ADR: UN 2811 6.1/PG 3
• 危险公开号: 22
• 保存温度: room temp
• 联合国危险货物等级: 6.1
• 联合国危险货物编号: 2811
• 联合国危险货物包装类别(PG): 3
• 德国WGK号: 3

产品详细信息

详细说明 (English)

Biochem/physiol Actions
Pilsicainide hydrochloride is a pure sodium channel blocker and an open channel blocker of Na+1 channels. Pilsicainide was defined as a pure sodium channel blocker. The compound is classified as a class Ic antiarrhythmic drug, and was originally developed in Japan. Similar to Lidocaine, Pilsicainide binds to open channels, but slowly. Pilsicainide is capable of selectively blocking the late currents in the mutant Na(+) channels that show dominant abnormal burst openings such as in δKPQ mutants. The compound is used to induce Brugada syndrome (BS) in animal models.

详细说明 (简体中文)

Biochem/physiol Actions
Pilsicainide hydrochloride is a pure sodium channel blocker and an open channel blocker of Na+1 channels. Pilsicainide was defined as a pure sodium channel blocker. The compound is classified as a class Ic antiarrhythmic drug, and was originally developed in Japan. Similar to Lidocaine, Pilsicainide binds to open channels, but slowly. Pilsicainide is capable of selectively blocking the late currents in the mutant Na(+) channels that show dominant abnormal burst openings such as in δKPQ mutants. The compound is used to induce Brugada syndrome (BS) in animal models.