BIMU8 hydrate

• 产品号: B4063
• CAS号: 134296-40-5(anhydrous)
• 分子式: C19H29ClN4O3
• 分子量: 396.91156
• 纯 度: ≥98% (HPLC)
• 保 存: desiccated

产品别名

• 标题: BIMU8 hydrate
• IUPAC标准名: N-[(1R,3R,5S)-8-methyl-8-azabicyclo[3.2.1]octan-3-yl]-2-oxo-3-(propan-2-yl)-2,3-dihydro-1H-1,3-benzodiazole-1-carboxamide hydrate hydrochloride
• IUPAC传统名: 3-isopropyl-N-[(1R,3R,5S)-8-methyl-8-azabicyclo[3.2.1]octan-3-yl]-2-oxo-1,3-benzodiazole-1-carboxamide hydrate hydrochloride
• 别名: 2,3-Dihydro-N-[(3-endo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl]-3-(1-methylethyl)-2-oxo-1H-benzimidazole-1-carboxamide Hydrochloride (1:1) hydrate

产品登记号

• CAS号: 134296-40-5(anhydrous)

产品性质

• Empirical Formula (Hill Notation): C19H26N4O2·HCl · xH2O
• 纯度: ≥98% (HPLC)
• 外观: off-white to light tan
• 溶解度: H2O: ≥5 mg/mL
• GHS警示词: Warning
• GHS危险声明: H315-H319-H335
• 欧盟危险性物质标志: 刺激性(Irritant) (Xi)
• GHS警示性声明: P261-P305 + P351 + P338
• 危险公开号: 36/37/38
• 安全公开号: 26
• 保存条件: desiccated
• 保存温度: 2-8°C
• 德国WGK号: 3

产品详细信息

详细说明 (English)

Biochem/physiol Actions
BIMU8 hydrate is a potent 5-HT4 serotonin receptor agonist. Serotonin (5-HT) is a major neurotransmitter that acts through a family of GPCRs and one ion channel. 5-HT4 receptor is GPCR expressed in many tissues, including brain, and modulates dopamine secretion, learning, and memory. BIMU8 is a full agonist at 5-HT4, but it binds differently than the endogenous ligand, 5-HT, shown through site-directed mutagenesis studies. It depolarizes neurons and was used to localize 5-HT4 to somatic but not dendritic regions of CA1 pyramidal neurons.

详细说明 (简体中文)

Biochem/physiol Actions
BIMU8 hydrate is a potent 5-HT4 serotonin receptor agonist. Serotonin (5-HT) is a major neurotransmitter that acts through a family of GPCRs and one ion channel. 5-HT4 receptor is GPCR expressed in many tissues, including brain, and modulates dopamine secretion, learning, and memory. BIMU8 is a full agonist at 5-HT4, but it binds differently than the endogenous ligand, 5-HT, shown through site-directed mutagenesis studies. It depolarizes neurons and was used to localize 5-HT4 to somatic but not dendritic regions of CA1 pyramidal neurons.