N-Methyl-L-tyrosine

• 产品号: 04632
• CAS号: 537-49-5
• 分子式: C10H13NO3
• 分子量: 195.21512
• 纯 度: ≥98% (HPLC)

产品别名

• 标题: N-Methyl-L-tyrosine
• IUPAC标准名: (2S)-3-(4-hydroxyphenyl)-2-(methylamino)propanoic acid
• IUPAC传统名: L-tyrosine, N-methyl-
• 别名: Surinamine; (S)-3-(4-Hydroxyphenyl)-2-(methylamino)propionic acid; N-Me-Tyr-OH

产品登记号

• MDL号: MFCD00238322
• CAS号: 537-49-5
• EC号: 208-670-8
• Beilstein号: 2646795

产品性质

• 主要成分: carbon, 60.7-62.3%
• 主要成分: nitrogen, 6.9-7.5%
• Empirical Formula (Hill Notation): C10H13NO3
• 纯度: ≥98% (HPLC)
• 比旋光度: [α]/D +16.0±1.0°, c = 1 in 1 M HCl
• GHS警示词: Warning
• GHS危险声明: H315-H319
• 欧盟危险性物质标志: 刺激性(Irritant) (Xi)
• GHS警示性声明: P305 + P351 + P338
• 危险公开号: 36-38
• 安全公开号: 26
• 德国WGK号: 3

产品详细信息

详细说明 (English)

Biochem/physiol Actions
N-Methyl amino acids play an important role in investigations on prevention or therapy of Alzheimer′s disease2, neurofibrillary tangles or amyloid plaque are physiological characteristics of this disease and ?-amyloid(40) fibrillogenesis and disassembly of ?-amyloid(40) fibrils is inhibited by short ?-amyloid congeners containing N-methyl amino acids at alternate residue.
Application
N-Methyl-L-tyrosine was used in experiments as a control group to show that methylation of the imino group in N-p-phenylpropionyl-L-tyrosine eliminates its inhibitory effect on the firing of the giant neurone of the giant African snail. 1

详细说明 (简体中文)

Biochem/physiol Actions
N-Methyl amino acids play an important role in investigations on prevention or therapy of Alzheimer′s disease2, neurofibrillary tangles or amyloid plaque are physiological characteristics of this disease and ?-amyloid(40) fibrillogenesis and disassembly of ?-amyloid(40) fibrils is inhibited by short ?-amyloid congeners containing N-methyl amino acids at alternate residue.
Application
N-Methyl-L-tyrosine was used in experiments as a control group to show that methylation of the imino group in N-p-phenylpropionyl-L-tyrosine eliminates its inhibitory effect on the firing of the giant neurone of the giant African snail. 1