(E/Z)-Endoxifen Hydrochloride Hydrate

• 产品号: E8284
• 分子式: C25H30ClNO3
• 分子量: 427.9636
• 纯 度: ≥98% (HPLC)
• 保 存: desiccated

产品别名

• 标题: (E/Z)-Endoxifen Hydrochloride Hydrate
• IUPAC标准名: 4-(1-{4-[2-(methylamino)ethoxy]phenyl}-2-phenylbut-1-en-1-yl)phenol hydrate hydrochloride
• IUPAC传统名: 4-(1-{4-[2-(methylamino)ethoxy]phenyl}-2-phenylbut-1-en-1-yl)phenol hydrate hydrochloride
• 别名: (E/Z)-4-Hydroxy-N-desmethyltamoxifen hydrochloride hydrate; (E/Z)-4-[1-[4-[2-(Methylamino)ethoxy]phenyl]-2-phenyl-1-buten-1-yl]-phenol hydrochloride hydrate (1:1 E/Z mixture); (E/Z)-4OHNDtam hydrochloride hydrate; (E/Z)-Endoxifen hydrochloride hydrate

产品登记号

• MDL号: MFCD16875406

产品性质

• Empirical Formula (Hill Notation): C25H27NO2 · HCl · xH2O
• 纯度: ≥98% (HPLC)
• 外观: white to beige solid
• 溶解度: DMSO: >10 mg/mL
• 保存条件: desiccated
• 保存温度: 2-8°C
• 德国WGK号: nwg

产品详细信息

详细说明 (English)

Biochem/physiol Actions
(E/Z)-Endoxifen hydrochloride ((E/Z)-4-Hydroxy-N-desmethyltamoxifen hydrochloride) is a tamoxifen metabolite and potent Selective Estrogen Response Modifier (SERM). It is equipotent to 4-hydroxytamoxifen with respect to estrogen receptor binding and inhibition of 17-estradiol (E2)-induced cell proliferation. It is primarily catalyzed by cytochrome P450 2D6 (CYP2D6). Mutations in CYP2D6 may prevent response to tamoxifen by preventing formation of endoxifen. The gene expression patterns of five genes have been validated to be differentially regulated by endoxifen and 4-OH-Tamoxifen. Endoxifen and 4-OH-Tam have similar effects on global gene expression patterns in MCF-7 cells and the majority of the affected genes are estrogen-regulated genes.

详细说明 (简体中文)

Biochem/physiol Actions
(E/Z)-Endoxifen hydrochloride ((E/Z)-4-Hydroxy-N-desmethyltamoxifen hydrochloride) is a tamoxifen metabolite and potent Selective Estrogen Response Modifier (SERM). It is equipotent to 4-hydroxytamoxifen with respect to estrogen receptor binding and inhibition of 17-estradiol (E2)-induced cell proliferation. It is primarily catalyzed by cytochrome P450 2D6 (CYP2D6). Mutations in CYP2D6 may prevent response to tamoxifen by preventing formation of endoxifen. The gene expression patterns of five genes have been validated to be differentially regulated by endoxifen and 4-OH-Tamoxifen. Endoxifen and 4-OH-Tam have similar effects on global gene expression patterns in MCF-7 cells and the majority of the affected genes are estrogen-regulated genes.