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Geranylgeranylacetone_分子结构_CAS_6809-52-5)
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Geranylgeranylacetone

产品号 G5048 公司名称 Sigma Aldrich
CAS号 6809-52-5 公司网站 http://www.sigmaaldrich.com
分子式 C23H38O 电 话 1-800-521-8956
分子量 330.54722 传 真
纯 度 ≥98% (HPLC) 电子邮件
保 存 protect from light Chembase数据库ID: 154595

产品价格信息

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产品别名

标题
Geranylgeranylacetone
IUPAC标准名
6,10,14,18-tetramethylnonadeca-5,9,13,17-tetraen-2-one
IUPAC传统名
6,10,14,18-tetramethylnonadeca-5,9,13,17-tetraen-2-one
别名
Teprenone
GGA
UNII-S8S8451A4O
Selbex
6,10,14,18-Tetramethyl-5,9,13,17-nonadecatetraen-2-one, mixture of (5E,9E,13E) and (5Z,9E,13E) isomers

产品登记号

MDL号 MFCD00869547
CAS号 6809-52-5

产品性质

Empirical Formula (Hill Notation) C23H38O
纯度 ≥98% (HPLC)
外观 clear liquid
溶解度 DMSO: >5 mg/mL
MSDS下载 下载链接
RTECS编号 RA5391300
保存条件 protect from light
保存温度 -20°C
德国WGK号 3

产品详细信息

详细说明 (English)
Biochem/physiol Actions
Geranylgeranylacetone can induce expression of HSP70, HSPB8, and HSPB1. Induction of HSP70 expression is protective against the development of various diseases, such as inflammatory bowel disease, hypoxic/ischemic brain injury and spinal and bulbar muscular atrophy (cytoprotective and anti-inflammatory effects). Reports indicate that GGA protects against NSAID-induced gastric and intestinal lesions by induction of HSP70 expression. Other studies have shown that GGA induces expression of HSPB8 and HSPB1 and reduces the formation of amyloid oligomers as well as insoluble aggregates in HSPB5 R120G TG mice.
详细说明 (简体中文)
Biochem/physiol Actions
Geranylgeranylacetone can induce expression of HSP70, HSPB8, and HSPB1. Induction of HSP70 expression is protective against the development of various diseases, such as inflammatory bowel disease, hypoxic/ischemic brain injury and spinal and bulbar muscular atrophy (cytoprotective and anti-inflammatory effects). Reports indicate that GGA protects against NSAID-induced gastric and intestinal lesions by induction of HSP70 expression. Other studies have shown that GGA induces expression of HSPB8 and HSPB1 and reduces the formation of amyloid oligomers as well as insoluble aggregates in HSPB5 R120G TG mice.

参考文献