SKA-31

• 产品号: S5576
• CAS号: 40172-65-4
• 分子式: C11H8N2S
• 分子量: 200.25962
• 纯 度: ≥98% (HPLC)

产品别名

• 标题: SKA-31
• IUPAC标准名: naphtho[1,2-d][1,3]thiazol-2-amine
• IUPAC传统名: naphtho[1,2-d][1,3]thiazol-2-amine
• 别名: Naphtho[1,2-d]thiazol-2-ylamine

产品登记号

• MDL号: MFCD00051329
• CAS号: 40172-65-4

产品性质

• Empirical Formula (Hill Notation): C11H8N2S
• 纯度: ≥98% (HPLC)
• 外观: solid
• 溶解度: DMSO: ≥30 mg/mL
• GHS警示词: Warning
• GHS危险声明: H302-H319
• 欧盟危险性物质标志: 有害性(Harmful) (Xn)
• GHS警示性声明: P305 + P351 + P338
• 危险公开号: 22-36
• 安全公开号: 26
• 保存温度: -20°C

产品详细信息

详细说明 (English)

Biochem/physiol Actions
SKA-31 is an activator of KCa2 and KCa3.1 calcium-activated potassium channels. Its EC50 is almost identical at 2-3 μM for all KCa2 subtypes, and about 10-fold lower (260 nM) at KCa3.1 channels. It has significant blood-pressure reducing activity in experimentally hypertensive mice,1 suggesting potassium channel activation as a therapeutic target for hypertension.
SKA31 is an activator of KCa2 and KCa3.1 Potassium Channels, Potentiates the EDHF Response and Lowers Blood Pressure.

详细说明 (简体中文)

Biochem/physiol Actions
SKA-31 is an activator of KCa2 and KCa3.1 calcium-activated potassium channels. Its EC50 is almost identical at 2-3 μM for all KCa2 subtypes, and about 10-fold lower (260 nM) at KCa3.1 channels. It has significant blood-pressure reducing activity in experimentally hypertensive mice,1 suggesting potassium channel activation as a therapeutic target for hypertension.
SKA31 is an activator of KCa2 and KCa3.1 Potassium Channels, Potentiates the EDHF Response and Lowers Blood Pressure.