GSK3787

• 产品号: G7423
• CAS号: 188591-46-0
• 分子式: C15H12ClF3N2O3S
• 分子量: 392.7805896
• 纯 度: ≥98% (HPLC)
• 保 存: desiccated

产品别名

• 标题: GSK3787
• IUPAC标准名: 4-chloro-N-(2-{[5-(trifluoromethyl)pyridin-2-yl]sulfonyl}ethyl)benzamide
• IUPAC传统名: 4-chloro-N-{2-[5-(trifluoromethyl)pyridin-2-ylsulfonyl]ethyl}benzamide
• 别名: 4-Chloro-N-(2-{[5-trifluoromethyl)-2-pyridyl]sulfonyl}ethyl)benzamide

产品登记号

• MDL号: MFCD00099612
• CAS号: 188591-46-0

产品性质

• Empirical Formula (Hill Notation): C15H12ClF3N2O3S
• 纯度: ≥98% (HPLC)
• 外观: white to off-white powder
• 溶解度: DMSO: ≥10 mg/mL
• GHS警示词: Warning
• GHS危险声明: H319
• 欧盟危险性物质标志: 刺激性(Irritant) (Xi)
• GHS警示性声明: P305 + P351 + P338
• 危险公开号: 36
• 安全公开号: 26
• 保存条件: desiccated
• 保存温度: 2-8°C
• 德国WGK号: 3

产品详细信息

详细说明 (English)

Biochem/physiol Actions
GSK3787 is an orally available selective irreversible Peroxisome Proliferator-Activated Receptor δ (PPARδ) antagonist (pIC50=6.6) with no measurable affinity for hPPARR or hPPARγ (pIC50<5). It acts by covalently modifying Cys249 within the ligand binding pocket, and has been shown to antagonize the induction of PPARδ-regulated target genes in skeletal muscle cells.

详细说明 (简体中文)

Biochem/physiol Actions
GSK3787 is an orally available selective irreversible Peroxisome Proliferator-Activated Receptor δ (PPARδ) antagonist (pIC50=6.6) with no measurable affinity for hPPARR or hPPARγ (pIC50<5). It acts by covalently modifying Cys249 within the ligand binding pocket, and has been shown to antagonize the induction of PPARδ-regulated target genes in skeletal muscle cells.