SYUIQ-5

• 产品号: S5826
• CAS号: 188630-47-9
• 分子式: C20H22N4
• 分子量: 318.41548
• 纯 度: ≥98% (HPLC)

产品别名

• 标题: SYUIQ-5
• IUPAC标准名: [3-({10H-indolo[3,2-b]quinolin-11-yl}amino)propyl]dimethylamine
• IUPAC传统名: (3-{10H-indolo[3,2-b]quinolin-11-ylamino}propyl)dimethylamine
• 别名: N′-(10H-Indolo [3,2-b]quinolin-11-yl)-N, N-dimethyl-propane-1,3-diamine

产品登记号

• CAS号: 188630-47-9
• MDL号: MFCD17215940

产品性质

• Empirical Formula (Hill Notation): C20H22N4
• 纯度: ≥98% (HPLC)
• 外观: yellow powder
• 溶解度: DMSO: ≥20 mg/mL
• GHS警示词: Warning
• GHS危险声明: H400
• 欧盟危险性物质标志: 环境危害性(Nature polluting) (N)
• GHS警示性声明: P273
• 危险公开号: 50
• 安全公开号: 61
• 保存温度: 2-8°C
• 德国WGK号: 2

产品详细信息

详细说明 (English)

Biochem/physiol Actions
SYUIQ-5 is a Cryptolepine derivative, which induces and stabilizes G-quadruplexes. In CNE2 and HeLa cancer cells SYUIQ-5 triggers rapid and potent telomere DNA damage through TRF2 delocalization from telomeres and induces cell death by autophagy. In low concentration the compound caused senescence and telomere shortening. It is a potent cytotoxic agent.

详细说明 (简体中文)

Biochem/physiol Actions
SYUIQ-5 is a Cryptolepine derivative, which induces and stabilizes G-quadruplexes. In CNE2 and HeLa cancer cells SYUIQ-5 triggers rapid and potent telomere DNA damage through TRF2 delocalization from telomeres and induces cell death by autophagy. In low concentration the compound caused senescence and telomere shortening. It is a potent cytotoxic agent.