10074-G5

• 产品号: G3798
• CAS号: 413611-93-5
• 分子式: C18H12N4O3
• 分子量: 332.31288
• 纯 度: ≥98% (HPLC)

产品别名

• 标题: 10074-G5
• IUPAC标准名: 7-nitro-N-(2-phenylphenyl)-2,1,3-benzoxadiazol-4-amine
• IUPAC传统名: 7-nitro-N-(2-phenylphenyl)-2,1,3-benzoxadiazol-4-amine
• 别名: N-[1,1′-Biphenyl-2-yl]-7-nitro-2,1,3-Benzoxadiazol-4-amine; N-2-Biphenylyl-7-nitro-2,1,3-benzoxadiazol-4-amine; Biphenyl-2-yl-(7-nitrobenzo[1,2,5]oxadiazol-4-yl)amine

产品登记号

• MDL号: MFCD00576774
• CAS号: 413611-93-5

产品性质

• Empirical Formula (Hill Notation): C18H12N4O3
• 纯度: ≥98% (HPLC)
• 外观: red powder
• 溶解度: DMSO: >10 mg/mL
• GHS警示词: Danger
• GHS危险声明: H301-H315-H319-H335
• 欧盟危险性物质标志: 有毒(Toxic) (T)
• GHS警示性声明: P261-P301 + P310-P305 + P351 + P338
• RID/ADR: UN 2811 6.1/PG 3
• 危险公开号: 25-36/37/38
• 安全公开号: 26-45
• 保存温度: room temp
• 联合国危险货物等级: 6.1
• 联合国危险货物编号: 2811
• 联合国危险货物包装类别(PG): 3
• 德国WGK号: 3

产品详细信息

详细说明 (English)

Biochem/physiol Actions
10074-G5 is a c-Myc/Max interaction inhibitor. The c-Myc oncoprotein and its partner Max are intrinsically disordered (ID) monomers that undergo coupled folding and binding upon heterodimerization. 10074-G5, similarly to 10058-F4 (#F3680), specifically inhibits this interaction by binding to c-Myc, thus preventing C-Myc specific DNA binding and target genes regulation. 10074-G5 (2.8 microM) is slightly more potent that 10058-F4 (5.2 microM). It was discovered that 10074-G5 binds to a different specific binding site (region) of C-Myc than 10054-F4. Thus, the compound may become desirable for probing different interactions.

详细说明 (简体中文)

Biochem/physiol Actions
10074-G5 is a c-Myc/Max interaction inhibitor. The c-Myc oncoprotein and its partner Max are intrinsically disordered (ID) monomers that undergo coupled folding and binding upon heterodimerization. 10074-G5, similarly to 10058-F4 (#F3680), specifically inhibits this interaction by binding to c-Myc, thus preventing C-Myc specific DNA binding and target genes regulation. 10074-G5 (2.8 microM) is slightly more potent that 10058-F4 (5.2 microM). It was discovered that 10074-G5 binds to a different specific binding site (region) of C-Myc than 10054-F4. Thus, the compound may become desirable for probing different interactions.