T3MG

• 产品号: T2455
• CAS号: 63088-04-0
• 分子式: C6H11NO4
• 分子量: 161.15584
• 纯 度: (single spot, TLC)

产品别名

• 标题: T3MG
• IUPAC标准名: (2R,3S)-2-amino-3-methylpentanedioic acid
• IUPAC传统名: (3r)-3-methyl-L-glutamic acid
• 别名: 3MG; (±)-threo-3-Methylglutamic acid; threo-3-Methylglutamate

产品登记号

• CAS号: 63088-04-0
• MDL号: MFCD09836097

产品性质

• Empirical Formula (Hill Notation): C6H11NO4
• 纯度: (single spot, TLC)
• 外观: white to off-white powder
• 溶解度: H2O: >1.5 mg/dL
• GHS警示词: Warning
• GHS危险声明: H315-H319-H335
• 欧盟危险性物质标志: 刺激性(Irritant) (Xi)
• GHS警示性声明: P261-P305 + P351 + P338
• 危险公开号: 36/37/38
• 安全公开号: 26
• 保存温度: room temp
• 德国WGK号: 3

产品详细信息

详细说明 (English)

Biochem/physiol Actions
T3MG is a selective inhibitor of excitatory amino acid transporters GLT-1, EAAT2, and EAAT4. T3MG has long been utilized as a gold standard in the study of general EAAT function. It has more recently been shown to be selective for EAAT2 and EAAT4 as compared to EAAT1 and EAAT3 in electrophysiology and glutamate/aspartate uptake assays. Although there are other EAAT2-selective compounds, this is the first tool with selectivity for EAAT4. T3MG is not a substrate for the transporters themselves, nor does it have activity at glutamate ion channels.

详细说明 (简体中文)

Biochem/physiol Actions
T3MG is a selective inhibitor of excitatory amino acid transporters GLT-1, EAAT2, and EAAT4. T3MG has long been utilized as a gold standard in the study of general EAAT function. It has more recently been shown to be selective for EAAT2 and EAAT4 as compared to EAAT1 and EAAT3 in electrophysiology and glutamate/aspartate uptake assays. Although there are other EAAT2-selective compounds, this is the first tool with selectivity for EAAT4. T3MG is not a substrate for the transporters themselves, nor does it have activity at glutamate ion channels.