Pyronaridine tetraphosphate

• 产品号: P0049
• CAS号: 76748-86-2
• 分子式: C29H44ClN5O18P4
• 分子量: 910.030404
• 纯 度: ≥95% (HPLC)

产品别名

• 标题: Pyronaridine tetraphosphate
• IUPAC标准名: 4-({7-chloro-2-methoxybenzo[b]1,5-naphthyridin-10-yl}amino)-2,6-bis(pyrrolidin-1-ylmethyl)phenol; tetrakis(phosphoric acid)
• IUPAC传统名: tetrakis(phosphoric acid); pyronaridine
• 别名: 2-Methoxy-7-chloro-10[3′,5′-bis(pyrrolidinyl-1-methyl-)4′-hydroxyphenyl]aminobenzyl-(b)-1,5-naphthyridine tetraphosphate

产品登记号

• CAS号: 76748-86-2
• MDL号: MFCD05863545

产品性质

• Empirical Formula (Hill Notation): C29H32ClN5O2·4H3PO4
• 纯度: ≥95% (HPLC)
• GHS警示词: Danger
• GHS危险声明: H301-H318-H361-H413
• 欧盟危险性物质标志: 有害性(Harmful) (Xn)
• 个人保护装置: dust mask type N95 (US), Eyeshields, Faceshields, Gloves
• GHS警示性声明: P280-P301 + P310-P305 + P351 + P338
• 危险公开号: 63-22-41
• RTECS编号: SK4920000
• 安全公开号: 26-36/37-39
• 保存温度: 2-8°C
• 德国WGK号: 2

产品详细信息

详细说明 (English)

Biochem/physiol Actions
Pyronaridine blocks β-hematin formation in vitro3 and has inhibitory activity toward P-glycoprotein mediated drug resistance.4 Antimalarial used on conjunction with artensunate.5
Pyronaridine has antimalarial activity. It is antagonistic against naphthoquine and dihydroartemisinin2. Pyronaridine blocks β-hematin formation in vitro3 and has inhibitory activity toward P-glycoprotein mediated drug resistance.4
Application
Pyronaridine, an acridine derivative, is an antimalarial drug. It is used in China as a treatment for drug-resistant falciparum malaria1. It′s in vitro activities have been studies against Plasmodium falciparum in Cameroon2.

详细说明 (简体中文)

Biochem/physiol Actions
Pyronaridine blocks β-hematin formation in vitro3 and has inhibitory activity toward P-glycoprotein mediated drug resistance.4 Antimalarial used on conjunction with artensunate.5
Pyronaridine has antimalarial activity. It is antagonistic against naphthoquine and dihydroartemisinin2. Pyronaridine blocks β-hematin formation in vitro3 and has inhibitory activity toward P-glycoprotein mediated drug resistance.4
Application
Pyronaridine, an acridine derivative, is an antimalarial drug. It is used in China as a treatment for drug-resistant falciparum malaria1. It′s in vitro activities have been studies against Plasmodium falciparum in Cameroon2.