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Calcipotriol hydrate

产品号 C4369 公司名称 Sigma Aldrich
CAS号 112965-21-6(anhydrous) 公司网站 http://www.sigmaaldrich.com
分子式 C27H42O4 电 话 1-800-521-8956
分子量 430.61998 传 真
纯 度 ≥99% (HPLC) 电子邮件
保 存 Chembase数据库ID: 154550

产品价格信息

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产品别名

标题
Calcipotriol hydrate
IUPAC标准名
(1R,3S)-5-{2-[(1R,3aS,7aR)-1-[(2R,5S)-5-cyclopropyl-5-hydroxypent-3-en-2-yl]-7a-methyl-octahydro-1H-inden-4-ylidene]ethylidene}-4-methylidenecyclohexane-1,3-diol hydrate
IUPAC传统名
(1R,3S)-5-{2-[(1R,3aS,7aR)-1-[(2R,5S)-5-cyclopropyl-5-hydroxypent-3-en-2-yl]-7a-methyl-hexahydro-1H-inden-4-ylidene]ethylidene}-4-methylidenecyclohexane-1,3-diol hydrate
别名
Calcipotriene
(5Z,7E,22E,24S)-24-Cyclopropyl-9,10-secochola-5,7,10(19),22-tetraene-1alpha,3beta,24-triol

产品登记号

MDL号 MFCD10567086
CAS号 112965-21-6(anhydrous)

产品性质

Empirical Formula (Hill Notation) C27H40O3 · xH2O
纯度 ≥99% (HPLC)
外观 solid
溶解度 DMSO: ≥24 mg/mL
GHS危险品标识 GHS06
GHS警示词 Danger
GHS危险声明 H310-H315-H319-H335
欧盟危险性物质标志 刺激性(Irritant) 刺激性(Irritant) (Xi)
MSDS下载 下载链接
个人保护装置 dust mask type N95 (US), Eyeshields, Faceshields, Gloves
GHS警示性声明 P261-P280-P302 + P350-P305 + P351 + P338-P310
危险公开号 36/37/38
RTECS编号 VS2830000
安全公开号 26
保存温度 room temp
德国WGK号 3

产品详细信息

详细说明 (English)
Biochem/physiol Actions
Calcipotriol, a synthetic derivative of calcitriol or Vitamin D, is used in the treatment of psoriasis and marketed under the trade name Dovonex. It has comparable affinity with calcitriol (Vit. D) for the Vitamin D receptor (VDR), while being less than 1% as active as the calcitriol in regulating calcium metabolism. VDR belongs to the steroid/thyroid receptor superfamily, and is found on the cells of many different tissues including the thyroid, bone, kindney, and T cells of the immune system. Binding of calcipotriol to the VDR modulates the T cells gene transcription of cell differentiation and proliferation-related genes.
详细说明 (简体中文)
Biochem/physiol Actions
Calcipotriol, a synthetic derivative of calcitriol or Vitamin D, is used in the treatment of psoriasis and marketed under the trade name Dovonex. It has comparable affinity with calcitriol (Vit. D) for the Vitamin D receptor (VDR), while being less than 1% as active as the calcitriol in regulating calcium metabolism. VDR belongs to the steroid/thyroid receptor superfamily, and is found on the cells of many different tissues including the thyroid, bone, kindney, and T cells of the immune system. Binding of calcipotriol to the VDR modulates the T cells gene transcription of cell differentiation and proliferation-related genes.

参考文献