Src Inhibitor-1

• 产品号: S2075
• CAS号: 179248-59-0
• 分子式: C22H19N3O3
• 分子量: 373.40456
• 纯 度: ≥98% (HPLC)
• 保 存: desiccated

产品别名

• 标题: Src Inhibitor-1
• IUPAC标准名: 6,7-dimethoxy-N-(4-phenoxyphenyl)quinazolin-4-amine
• IUPAC传统名: 6,7-dimethoxy-N-(4-phenoxyphenyl)quinazolin-4-amine
• 别名: 6,7-Dimethoxy-N-(4-phenoxyphenyl)-4-quinazolinamine; Src-l1; SKI-1; 4-(4′-Phenoxyanilino)-6,7-dimethoxyquinazoline

产品登记号

• MDL号: MFCD01815300
• CAS号: 179248-59-0

产品性质

• GHS警示词: Warning
• GHS危险声明: H302-H315-H319-H335-H413
• 欧盟危险性物质标志: 有害性(Harmful) (Xn)
• GHS警示性声明: P261-P305 + P351 + P338
• RID/ADR: UN 2811 6.1/PG 3
• 危险公开号: 22-36/37/38
• 安全公开号: 26
• 保存条件: desiccated
• 保存温度: 2-8°C
• 联合国危险货物等级: 6.1
• 联合国危险货物编号: 2811
• 联合国危险货物包装类别(PG): 3
• 德国WGK号: 3
• Empirical Formula (Hill Notation): C22H19N3O3
• 纯度: ≥98% (HPLC)
• 外观: white powder
• 溶解度: DMSO: >10 mg/mL

产品详细信息

详细说明 (English)

Biochem/physiol Actions
Src Inhibitor-1 is a potent, competitve dual site (both the ATP- and peptide-binding) Src kinase inhibitor. Src Inhibitor-1 is one of the "gold standards" for Src kinase inhibition. It has been shown to use PP1 or PP2 in parallel with Src-I1 to inhbit Src family kinases. Src Inhibitor-1 is a selective, competitive inhibitor of Src family of tyrosine kinases (IC50 = 44 nM and 88 nM for Src and Lck, respectively). Src Inhibitor-1 Inhibits VEGFR2 and c-fms tyrosine kinases at much higher concentrations (IC50 = 0.32 μM and 30 μM, respectively).

详细说明 (简体中文)

Biochem/physiol Actions
Src Inhibitor-1 is a potent, competitve dual site (both the ATP- and peptide-binding) Src kinase inhibitor. Src Inhibitor-1 is one of the "gold standards" for Src kinase inhibition. It has been shown to use PP1 or PP2 in parallel with Src-I1 to inhbit Src family kinases. Src Inhibitor-1 is a selective, competitive inhibitor of Src family of tyrosine kinases (IC50 = 44 nM and 88 nM for Src and Lck, respectively). Src Inhibitor-1 Inhibits VEGFR2 and c-fms tyrosine kinases at much higher concentrations (IC50 = 0.32 μM and 30 μM, respectively).