CPPHA

• 产品号: C2247
• CAS号: 693288-97-0
• 分子式: C22H15ClN2O4
• 分子量: 406.8185
• 纯 度: ≥98% (HPLC)
• 保 存: desiccated

产品别名

• 标题: CPPHA
• IUPAC标准名: N-{4-chloro-2-[(1,3-dioxo-2,3-dihydro-1H-isoindol-2-yl)methyl]phenyl}-2-hydroxybenzamide
• IUPAC传统名: N-{4-chloro-2-[(1,3-dioxoisoindol-2-yl)methyl]phenyl}-2-hydroxybenzamide
• 别名: N-[4-Chloro-2-(phthalimidomethyl)phenyl]salicylamide; N-[4-Chloro-2-[(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl]phenyl}-2-hydroxybenzamide

产品登记号

• MDL号: MFCD12912405
• CAS号: 693288-97-0

产品性质

• Empirical Formula (Hill Notation): C22H15ClN2O4
• 纯度: ≥98% (HPLC)
• 外观: solid
• 溶解度: DMSO: >20 mg/mL
• GHS警示词: Warning
• GHS危险声明: H410
• 欧盟危险性物质标志: 环境危害性(Nature polluting) (N)
• GHS警示性声明: P273-P501
• RID/ADR: UN 3077 9/PG 3
• 危险公开号: 50/53
• 安全公开号: 60-61
• 保存条件: desiccated
• 保存温度: -20°C
• 联合国危险货物等级: 9
• 联合国危险货物编号: 3077
• 联合国危险货物包装类别(PG): 3
• 德国WGK号: 3

产品详细信息

详细说明 (English)

Biochem/physiol Actions
CPPHA is a selective positive allosteric modulator of mGluR5 receptor. It has no agonist activity alone, but reduces threshold response and shifts dose-response curves to glutamate, quisqualate, and DHPG by 4- to 7-fold to the left in recombinant CHO cells expressing human or rat mGluR5.

详细说明 (简体中文)

Biochem/physiol Actions
CPPHA is a selective positive allosteric modulator of mGluR5 receptor. It has no agonist activity alone, but reduces threshold response and shifts dose-response curves to glutamate, quisqualate, and DHPG by 4- to 7-fold to the left in recombinant CHO cells expressing human or rat mGluR5.