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PNU-74654
产品号	P0052	公司名称	Sigma Aldrich
CAS号	113906-27-7	公司网站	http://www.sigmaaldrich.com
分子式	C19H16N2O3	电话	1-800-521-8956
分子量	320.34194	传真
纯度	≥98% (HPLC)	电子邮件
保存		Chembase数据库ID: 154525

产品价格信息

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产品别名

标题

PNU-74654

IUPAC标准名

N'-[(5-methylfuran-2-yl)methylidene]-2-phenoxybenzohydrazide

IUPAC传统名

N'-[(5-methylfuran-2-yl)methylidene]-2-phenoxybenzohydrazide

别名

Benzoic acid, 2-phenoxy-, 2-[(5-methyl-2-furanyl)methylene]hydrazide

产品登记号

MDL号	MFCD12912438
CAS号	113906-27-7

产品性质

Empirical Formula (Hill Notation)	C19H16N2O3
纯度	≥98% (HPLC)
外观	white to off-white solid
溶解度	DMSO: >10 mg/mL
GHS危险品标识
GHS警示词	Warning
GHS危险声明	H302
欧盟危险性物质标志	有害性(Harmful) (Xn)
MSDS下载	下载链接
个人保护装置	dust mask type N95 (US), Eyeshields, Gloves
危险公开号	22
保存温度	2-8°C
德国WGK号	3

产品详细信息

详细说明 (English)

Biochem/physiol Actions
PNU-74654 inhibits the Wnt-β catenin pathway by blocking the interaction between β-catenin and TCF (T cell factor). PNU-74654 is also an anti-tumor agent. Aberrant activation of the Wnt/β-catenin pathway (canonical pathway) is implicated in driving development/progression of different tumors, such as colon cancer, through interaction between β-catenin and T cell factor (TCF), which regulates the expression of target genes in cell proliferation and differentiation. Inhibition of this pathway activity in cancer cell lines efficiently blocks their growth. PNU-74654 inhibits this pathway by blocking the interaction between β-catenin and TCF.

详细说明 (简体中文)

Biochem/physiol Actions
PNU-74654 inhibits the Wnt-β catenin pathway by blocking the interaction between β-catenin and TCF (T cell factor). PNU-74654 is also an anti-tumor agent. Aberrant activation of the Wnt/β-catenin pathway (canonical pathway) is implicated in driving development/progression of different tumors, such as colon cancer, through interaction between β-catenin and T cell factor (TCF), which regulates the expression of target genes in cell proliferation and differentiation. Inhibition of this pathway activity in cancer cell lines efficiently blocks their growth. PNU-74654 inhibits this pathway by blocking the interaction between β-catenin and TCF.