EF-24

• 产品号: E8409
• CAS号: 342808-40-6
• 分子式: C19H16ClF2NO
• 分子量: 347.7862464
• 纯 度: ≥98% (HPLC)

产品别名

• 标题: EF-24
• IUPAC标准名: 3,5-bis[(2-fluorophenyl)methylidene]piperidin-4-one hydrochloride
• IUPAC传统名: 3,5-bis[(2-fluorophenyl)methylidene]piperidin-4-one hydrochloride
• 别名: (3E,5E)-3,5-bis[(2-fluorophenyl)methylene]-4-piperidinone

产品登记号

• CAS号: 342808-40-6

产品性质

• Empirical Formula (Hill Notation): C19H15F2NO
• 纯度: ≥98% (HPLC)
• 外观: yellow powder
• 溶解度: DMSO: ≥10 mg/mL
• GHS警示词: Warning
• GHS危险声明: H302-H400
• 欧盟危险性物质标志: 有害性(Harmful) (Xn)
• 欧盟危险性物质标志: 环境危害性(Nature polluting) (N)
• GHS警示性声明: P273
• RID/ADR: UN 3077 9/PG 3
• 危险公开号: 22-50
• 安全公开号: 61
• 保存温度: -20°C
• 联合国危险货物等级: 9
• 联合国危险货物编号: 3077
• 联合国危险货物包装类别(PG): 3
• 德国WGK号: 3

产品详细信息

详细说明 (English)

Biochem/physiol Actions
EF-24 is a IKK inhibitor and curcumin analog. EF-24 is more potent and bioavailable than curcumin, with 10-fold greater potency in cell death induction. It is also more efficacious in anti-cancer screens and less toxic than Cisplatin. EF-24 inhibits HIF-1alpha posttranscriptional activity and induces microtubule stabilization, in contrast to Curcumin. EF-24 up-regulates PTEN expression via inhibition of ubiquitination. EF-24 induces cell death through direct inhibition of IkappaB kinase (IKK), resulting in suppression in NFκB activity.

详细说明 (简体中文)

Biochem/physiol Actions
EF-24 is a IKK inhibitor and curcumin analog. EF-24 is more potent and bioavailable than curcumin, with 10-fold greater potency in cell death induction. It is also more efficacious in anti-cancer screens and less toxic than Cisplatin. EF-24 inhibits HIF-1alpha posttranscriptional activity and induces microtubule stabilization, in contrast to Curcumin. EF-24 up-regulates PTEN expression via inhibition of ubiquitination. EF-24 induces cell death through direct inhibition of IkappaB kinase (IKK), resulting in suppression in NFκB activity.