S-PMH

• 产品号: S0826
• 分子式: C12H12N2O2S
• 分子量: 248.30088
• 纯 度: ≥98% (HPLC)

产品别名

• 标题: S-PMH
• IUPAC标准名: 5-{[4-(ethylsulfanyl)phenyl]methylidene}imidazolidine-2,4-dione
• IUPAC传统名: 5-{[4-(ethylsulfanyl)phenyl]methylidene}imidazolidine-2,4-dione
• 别名: (Z)-5-(4-(ethylthio)benzylidene)-hydantoin; 5-(4-Ethylsulfanylbenzylidene)imidazolidine-2,4-dione; (Z)-5-[4-(Ethylthio)benzylidene]imidazolidine-2,4-dione

产品登记号

• MDL号: MFCD12912441

产品性质

• Empirical Formula (Hill Notation): C12H12N2O2S
• 纯度: ≥98% (HPLC)
• 外观: yellow powder
• 溶解度: DMSO: >20 mg/mL
• 保存温度: 2-8°C
• 德国WGK号: 3

产品详细信息

详细说明 (English)

Biochem/physiol Actions
S-PMH augments cell-cell adhesion by enhancing tight and adherens junctions (TJ and AJ) and by abolishing the destabilizing actions of Calcitonin (CT) on these complexes. Calcitonin and its receptor are expressed in prostate cell cancers and plays a pivotal role in metastasis and tumorgenesis. It appears that CT promotes prostate cancer metastasis by reducing cell-cell adhesion through the disassembly of tight and adherens junctions and activation of B-catenin signaling. S-PMH apparently blocks CT-stimulated alphavbeta3 activity (a key factor in bone metastasis). In a nude mice model I.p. administered S-PMH and its S-ethyl derivative decreased orthotopic tumor growth and inhibited the formation of tumor micrometastases in distant organs. S-PMH is relatively nontoxic in a cell proliferation assay.

详细说明 (简体中文)

Biochem/physiol Actions
S-PMH augments cell-cell adhesion by enhancing tight and adherens junctions (TJ and AJ) and by abolishing the destabilizing actions of Calcitonin (CT) on these complexes. Calcitonin and its receptor are expressed in prostate cell cancers and plays a pivotal role in metastasis and tumorgenesis. It appears that CT promotes prostate cancer metastasis by reducing cell-cell adhesion through the disassembly of tight and adherens junctions and activation of B-catenin signaling. S-PMH apparently blocks CT-stimulated alphavbeta3 activity (a key factor in bone metastasis). In a nude mice model I.p. administered S-PMH and its S-ethyl derivative decreased orthotopic tumor growth and inhibited the formation of tumor micrometastases in distant organs. S-PMH is relatively nontoxic in a cell proliferation assay.