GW9508

• 产品号: G9797
• CAS号: 885101-89-3
• 分子式: C22H21NO3
• 分子量: 347.40704
• 纯 度: ≥98% (HPLC)

产品别名

• 标题: GW9508
• IUPAC标准名: 3-(4-{[(3-phenoxyphenyl)methyl]amino}phenyl)propanoic acid
• IUPAC传统名: 3-(4-{[(3-phenoxyphenyl)methyl]amino}phenyl)propanoic acid
• 别名: 4-(3-Phenoxybenzylamino)phenylpropionic acid

产品登记号

• CAS号: 885101-89-3
• MDL号: MFCD09753282

产品性质

• Empirical Formula (Hill Notation): C22H21NO3
• 纯度: ≥98% (HPLC)
• 外观: white powder
• 溶解度: DMSO: >20 mg/mL
• GHS警示词: Danger
• GHS危险声明: H302-H315-H318-H335-H410
• 欧盟危险性物质标志: 有害性(Harmful) (Xn)
• 欧盟危险性物质标志: 环境危害性(Nature polluting) (N)
• 个人保护装置: dust mask type N95 (US), Eyeshields, Faceshields, Gloves
• GHS警示性声明: P261-P273-P280-P305 + P351 + P338-P501
• RID/ADR: UN 3077 9/PG 3
• 危险公开号: 22-37/38-41-50/53
• 安全公开号: 26-39-60-61
• 保存温度: 2-8°C
• 联合国危险货物等级: 9
• 联合国危险货物编号: 3077
• 联合国危险货物包装类别(PG): 3
• 德国WGK号: 3

产品详细信息

详细说明 (English)

Biochem/physiol Actions
GW9508 is a selective FFA1/GPR40 agonist. GPR40 was formerly an orphan G protein-coupled receptor whose endogenous ligands have now been identified as free fatty acids (FFAs). The receptor, named FFA receptor 1, has been implicated in the pathophysiology of type 2 diabetes and is a drug target because of its role in FFA-mediated enhancement of glucose-stimulated insulin release. GW9508 showed greater than 500-fold selectivity for GPR40 over GPR41 and GPR43 and possessed a good in vitro and in vivo profile with excellent bioavailability. GW9508 stimulated intracellular Ca2+ mobilization in human embryonic kidney HEK-293 cells expressing GPR40 or GPR120, but not in the parent HEK-293 cell line. GW9508 dose dependently potentiated glucose-stimulated insulin secretion in MIN6 cells, but not in primary rat or mouse islets. GW9508 potentiates the KCl-mediated increase in insulin secretion in MIN6 cells.

详细说明 (简体中文)

Biochem/physiol Actions
GW9508 is a selective FFA1/GPR40 agonist. GPR40 was formerly an orphan G protein-coupled receptor whose endogenous ligands have now been identified as free fatty acids (FFAs). The receptor, named FFA receptor 1, has been implicated in the pathophysiology of type 2 diabetes and is a drug target because of its role in FFA-mediated enhancement of glucose-stimulated insulin release. GW9508 showed greater than 500-fold selectivity for GPR40 over GPR41 and GPR43 and possessed a good in vitro and in vivo profile with excellent bioavailability. GW9508 stimulated intracellular Ca2+ mobilization in human embryonic kidney HEK-293 cells expressing GPR40 or GPR120, but not in the parent HEK-293 cell line. GW9508 dose dependently potentiated glucose-stimulated insulin secretion in MIN6 cells, but not in primary rat or mouse islets. GW9508 potentiates the KCl-mediated increase in insulin secretion in MIN6 cells.