K252c, Ready Made Solution

• 产品号: K1890
• 分子式: C20H13N3O
• 分子量: 311.33672
• 纯 度: >95% (HPLC)

产品别名

• 标题: K252c, Ready Made Solution
• IUPAC标准名: 3,13,23-triazahexacyclo[14.7.0.0^2,^1^0.0^4,^9.0^1^1,^1^5.0^1^7,^2^2]tricosa-1(16),2(10),4(9),5,7,11(15),17,19,21-nonaen-12-one
• IUPAC传统名: 3,13,23-triazahexacyclo[14.7.0.0^2,^1^0.0^4,^9.0^1^1,^1^5.0^1^7,^2^2]tricosa-1(16),2(10),4(9),5,7,11(15),17,19,21-nonaen-12-one
• 别名: Staurosporonine; Staurosporine aglycone; K-252c

产品登记号

• EC号: 200-664-3
• MDL号: MFCD00236435

产品性质

• 生物来源: from Streptomyces albus
• Empirical Formula (Hill Notation): C20H13N3O
• 纯度: >95% (HPLC)
• 运输包装: dry ice
• 相关基因信息: human ... CDK2(1017)
• 个人保护装置: Eyeshields, Gloves, half-mask respirator (US), multi-purpose combination respirator cartridge (US)
• 保存温度: -20°C
• 德国WGK号: 1

产品详细信息

详细说明 (English)

Physical form
Supplied as a 1.6 mM, 0.2 μm-filtered solution in dimethyl sulfoxide (DMSO).
Biochem/physiol Actions
K252c belongs to the K252 family of compounds, which are general and potent inhibitors of various protein kinases.1 K252c is a protein kinase C inhibitor, weaker than K252b (IC50 of K252c = 214 nM and IC50 of K252b = 38.3 nM).1 K252c is also a weak inhibitor of calcium/calmodulin-activated phosphodiesterase with IC50 values of 297 μM for the brain enzyme.1, K252c expresses potent cytotoxicity against lung cancer A549 cells in vitro with an IC50 of 2.0 μM and against P388, IC50 = 3.2 μM.2, K252c exhibits moderate cytotoxic activity against K562 cells and induces apoptotic responses at 10 μM.3

详细说明 (简体中文)

Physical form
Supplied as a 1.6 mM, 0.2 μm-filtered solution in dimethyl sulfoxide (DMSO).
Biochem/physiol Actions
K252c belongs to the K252 family of compounds, which are general and potent inhibitors of various protein kinases.1 K252c is a protein kinase C inhibitor, weaker than K252b (IC50 of K252c = 214 nM and IC50 of K252b = 38.3 nM).1 K252c is also a weak inhibitor of calcium/calmodulin-activated phosphodiesterase with IC50 values of 297 μM for the brain enzyme.1, K252c expresses potent cytotoxicity against lung cancer A549 cells in vitro with an IC50 of 2.0 μM and against P388, IC50 = 3.2 μM.2, K252c exhibits moderate cytotoxic activity against K562 cells and induces apoptotic responses at 10 μM.3