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LY-487379 hydrochloride_分子结构_CAS_353229-59-1)
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LY-487379 hydrochloride

产品号 L1170 公司名称 Sigma Aldrich
CAS号 353229-59-1 公司网站 http://www.sigmaaldrich.com
分子式 C21H20ClF3N2O4S 电 话 1-800-521-8956
分子量 488.9077096 传 真
纯 度 ≥98% (HPLC) 电子邮件
保 存 desiccated Chembase数据库ID: 154480

产品价格信息

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产品别名

标题
LY-487379 hydrochloride
IUPAC标准名
2,2,2-trifluoro-N-[4-(2-methoxyphenoxy)phenyl]-N-(pyridin-3-ylmethyl)ethane-1-sulfonamide hydrochloride
IUPAC传统名
2,2,2-trifluoro-N-[4-(2-methoxyphenoxy)phenyl]-N-(pyridin-3-ylmethyl)ethanesulfonamide hydrochloride
别名
N-(4-(2-Methoxyphenoxy)phenyl)-N-(2,2,2- trifluoroethylsulfonyl)pyrid-3-ylmethylamine hydrochloride

产品登记号

MDL号 MFCD11519970
CAS号 353229-59-1

产品性质

Empirical Formula (Hill Notation) C21H19F3N2O4SHCl
纯度 ≥98% (HPLC)
外观 off-white powder
溶解度 DMSO: >20 mg/mL
MSDS下载 下载链接
保存条件 desiccated
保存温度 2-8°C
德国WGK号 3

产品详细信息

详细说明 (English)
Biochem/physiol Actions
LY-487379 is a positive allosteric modulator of the metabotropic glutamate receptor mGluR2. EC50 = 1.7 μM. LY-487379 shows no intrinsic agonist or antagonist activity at hmGluR2 and has no activity at human mGluR3. LY-487379 markedly potentiates glutamate-stimulated [35S]GTPγS binding in a concentration-dependent manner at hmGluR2, shifting the glutamate dose-response curve leftward by 3-fold and increasing the maximum levels of [35S]GTPγS stimulation. LY-487379 has anxiolytic effects in fear-potentiated startle. This activity profile is useful in all symptom domains of schizophrenia.1
详细说明 (简体中文)
Biochem/physiol Actions
LY-487379 is a positive allosteric modulator of the metabotropic glutamate receptor mGluR2. EC50 = 1.7 μM. LY-487379 shows no intrinsic agonist or antagonist activity at hmGluR2 and has no activity at human mGluR3. LY-487379 markedly potentiates glutamate-stimulated [35S]GTPγS binding in a concentration-dependent manner at hmGluR2, shifting the glutamate dose-response curve leftward by 3-fold and increasing the maximum levels of [35S]GTPγS stimulation. LY-487379 has anxiolytic effects in fear-potentiated startle. This activity profile is useful in all symptom domains of schizophrenia.1

参考文献