BEPP monohydrochloride

• 产品号: B2938
• CAS号: 455311-98-5
• 分子式: C23H24ClN3O2
• 分子量: 409.90856
• 纯 度: ≥98% (HPLC)
• 保 存: desiccated

产品别名

• 标题: BEPP monohydrochloride
• IUPAC标准名: 1-(3-benzyl-2-imino-2,3-dihydro-1H-1,3-benzodiazol-1-yl)-3-phenoxypropan-2-ol hydrochloride
• IUPAC传统名: 1-(3-benzyl-2-imino-1,3-benzodiazol-1-yl)-3-phenoxypropan-2-ol hydrochloride
• 别名: 1H-Benzimidazole-1-ethanol, 2,3-dihydro-2-imino-alpha-(phenoxymethyl)-3-(phenylmethyl)- monohydrochloride

产品登记号

• MDL号: MFCD00964481
• CAS号: 455311-98-5

产品性质

• Empirical Formula (Hill Notation): C23H23N3O2 HCl
• 纯度: ≥98% (HPLC)
• 外观: white to off-white powder
• 溶解度: DMSO: >10 mg/mL
• 保存条件: desiccated
• 保存温度: 2-8°C
• 德国WGK号: 1

产品详细信息

详细说明 (English)

Biochem/physiol Actions
BEPP is a double-strand RNA-dependent protein kinase (PKR) activator. The double-strand RNA (dsRNA)-dependent protein kinase is a ubiquitously expressed serine threonine kinase, inducible by interferon γ. PRK is involved in several curtail cellular regulations including phosphorylation of eIF2α (which leads to inhibition of protein synthesis and eliciting antivirus and antitumor activities), modulating activities of eIF2α, NF-κB, ATF-3, and p53. BEPP also inhibits the growth of a human lung cancer cell line overexpressing PKR.

详细说明 (简体中文)

Biochem/physiol Actions
BEPP is a double-strand RNA-dependent protein kinase (PKR) activator. The double-strand RNA (dsRNA)-dependent protein kinase is a ubiquitously expressed serine threonine kinase, inducible by interferon γ. PRK is involved in several curtail cellular regulations including phosphorylation of eIF2α (which leads to inhibition of protein synthesis and eliciting antivirus and antitumor activities), modulating activities of eIF2α, NF-κB, ATF-3, and p53. BEPP also inhibits the growth of a human lung cancer cell line overexpressing PKR.