YM-202074 sesquifumarate salt hydrate

• 产品号: Y1271
• CAS号: 299900-84-8(anhydrous)
• 分子式: C74H100N12O15S3
• 分子量: 1493.8522
• 纯 度: ≥98% (HPLC)

产品别名

• 标题: YM-202074 sesquifumarate salt hydrate
• IUPAC标准名: tris(N-cyclohexyl-11-{[(2-methoxyethyl)(methyl)amino]methyl}-N-methyl-5-thia-2,7-diazatricyclo[6.4.0.0^2,^6]dodeca-1(12),3,6,8,10-pentaene-4-carboxamide) bis(but-2-enedioic acid) hydrate
• IUPAC传统名: tris(N-cyclohexyl-11-{[(2-methoxyethyl)(methyl)amino]methyl}-N-methyl-5-thia-2,7-diazatricyclo[6.4.0.0^2,^6]dodeca-1(12),3,6,8,10-pentaene-4-carboxamide) bis(butenedioic acid) hydrate
• 别名: YM 202074; YM202074; N-cyclohexyl-6-{[(2-methoxyethyl)(methyl)amino]methyl}-N-methylthiazolo[3,2-a]benzimidazole-2-carboxamide

产品登记号

• MDL号: MFCD16879020
• CAS号: 299900-84-8(anhydrous)

产品性质

• Empirical Formula (Hill Notation): C22H30N4O2S · 1.5C4H4O4 · xH2O
• 纯度: ≥98% (HPLC)
• 外观: white to off-white powder
• 溶解度: DMSO: >20 mg/mL
• 溶解度: H2O: >5 mg/mL
• GHS警示词: Danger
• GHS危险声明: H301-H319
• 欧盟危险性物质标志: 有毒(Toxic) (T)
• GHS警示性声明: P301 + P310-P305 + P351 + P338
• RID/ADR: UN 2811 6.1/PG 3
• 危险公开号: 25-36
• 安全公开号: 26-45
• 保存温度: room temp
• 联合国危险货物等级: 6.1
• 联合国危险货物编号: 2811
• 联合国危险货物包装类别(PG): 3
• 德国WGK号: 3

产品详细信息

详细说明 (English)

Biochem/physiol Actions
YM-202074 is a potent and selective allosteric metabotropic glutamate receptor type 1 (mGluR1) antagonist. It bound an allosteric site of rat mGluR1 with a Ki value of 4.8 nM. It also inhibited the mGluR1-mediated inositol phosphates production in rat cerebellar granule cells with an IC50 value of 8.6 nM, while showing selectivity over mGluR(2-7).

详细说明 (简体中文)

Biochem/physiol Actions
YM-202074 is a potent and selective allosteric metabotropic glutamate receptor type 1 (mGluR1) antagonist. It bound an allosteric site of rat mGluR1 with a Ki value of 4.8 nM. It also inhibited the mGluR1-mediated inositol phosphates production in rat cerebellar granule cells with an IC50 value of 8.6 nM, while showing selectivity over mGluR(2-7).