EX-527

• 产品号: E7034
• CAS号: 49843-98-3
• 分子式: C13H13ClN2O
• 分子量: 248.70812
• 纯 度: ≥98% (HPLC)

产品别名

• 标题: EX-527
• IUPAC标准名: 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide
• IUPAC传统名: 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide
• 别名: 6-Chloro-2,3,4,9-tetrahydro-1H-Carbazole-1-carboxamide

产品登记号

• MDL号: MFCD03009471
• CAS号: 49843-98-3

产品性质

• Empirical Formula (Hill Notation): C13H13ClN2O
• 纯度: ≥98% (HPLC)
• 外观: white to off-white powder
• 溶解度: DMSO: >20 mg/mL
• GHS警示词: Danger
• GHS危险声明: H301-H319
• 欧盟危险性物质标志: 有害性(Harmful) (Xn)
• GHS警示性声明: P301 + P310-P305 + P351 + P338
• RID/ADR: UN 2811 6.1/PG 3
• 危险公开号: 22-36
• 安全公开号: 26
• 保存温度: 2-8°C
• 联合国危险货物等级: 6.1
• 联合国危险货物编号: 2811
• 联合国危险货物包装类别(PG): 3
• 德国WGK号: 3

产品详细信息

详细说明 (简体中文)

Biochem/physiol Actions
Potent SIRT1 inhibitor, IC50 38 nM. More potent and selective than our current SIRT inhibitors. 200-500-fold more selective for SIRT1 than for SIRT2 or SIRT3. Does not inhibit SIRT4-7, does not inhibit class I/II HDAC activity at concentrations up to 100uM. Enhances p53 acetylation in response to DNA damaging agents. Mentioned in several reviews as well as recent Oncogene paper. EX-527 was identified in a high throughput screen. It is racemic and gives similar results and potency as the active isomer, EX-243, whereas the other isomer (designated EX-242) is inactive.

详细说明 (English)

Biochem/physiol Actions
Potent SIRT1 inhibitor, IC50 38 nM. More potent and selective than our current SIRT inhibitors. 200-500-fold more selective for SIRT1 than for SIRT2 or SIRT3. Does not inhibit SIRT4-7, does not inhibit class I/II HDAC activity at concentrations up to 100uM. Enhances p53 acetylation in response to DNA damaging agents. Mentioned in several reviews as well as recent Oncogene paper. EX-527 was identified in a high throughput screen. It is racemic and gives similar results and potency as the active isomer, EX-243, whereas the other isomer (designated EX-242) is inactive.