Salermide

• 产品号: S8825
• CAS号: 1105698-15-4
• 分子式: C26H22N2O2
• 分子量: 394.46508
• 纯 度: ≥98% (HPLC)
• 保 存: desiccated

产品别名

• 标题: Salermide
• IUPAC标准名: N-(3-{[(2-hydroxynaphthalen-1-yl)methylidene]amino}phenyl)-2-phenylpropanamide
• IUPAC传统名: N-(3-{[(2-hydroxynaphthalen-1-yl)methylidene]amino}phenyl)-2-phenylpropanamide
• 别名: N-{3-[(2-Hydroxy-naphthalen-1-ylmethylene)-amino]-phenyl}-2-phenyl-propionamide

产品登记号

• CAS号: 1105698-15-4
• MDL号: MFCD12912446

产品性质

• Empirical Formula (Hill Notation): C26H22N2O2
• 纯度: ≥98% (HPLC)
• 外观: powder, yellow
• 溶解度: DMSO: >10 mg/mL
• GHS警示词: Warning
• GHS危险声明: H317-H412
• 欧盟危险性物质标志: 刺激性(Irritant) (Xi)
• GHS警示性声明: P273-P280
• 危险公开号: 43-52/53
• 安全公开号: 36/37-61
• 保存条件: desiccated
• 保存温度: 2-8°C
• 德国WGK号: 3

产品详细信息

详细说明 (English)

Biochem/physiol Actions
Salermide is a novel Sirtuin 1 (Sirt1) and Sirtuin 2 (Sirt2) inhibitor (III histone deacetylases inhibitor). In vitro Salermide has a stronger inhibitory effect on Sirt2 than on Sirt1. Salermide induces massive apoptosis in tumor cells. The activity was ascribed to effect of Salermide to the reactivation of proapoptotic genes epigenetically repressed exclusively in cancer cells by Sirt1. Salermide is a stronger Sirtuin inhibitor than sirtinol (Cat. No.S7942).

详细说明 (简体中文)

Biochem/physiol Actions
Salermide is a novel Sirtuin 1 (Sirt1) and Sirtuin 2 (Sirt2) inhibitor (III histone deacetylases inhibitor). In vitro Salermide has a stronger inhibitory effect on Sirt2 than on Sirt1. Salermide induces massive apoptosis in tumor cells. The activity was ascribed to effect of Salermide to the reactivation of proapoptotic genes epigenetically repressed exclusively in cancer cells by Sirt1. Salermide is a stronger Sirtuin inhibitor than sirtinol (Cat. No.S7942).