CRT0044876

• 产品号: C0496
• CAS号: 6960-45-8
• 分子式: C9H6N2O4
• 分子量: 206.15494
• 纯 度: ≥98% (HPLC)

产品别名

• 标题: CRT0044876
• IUPAC标准名: 7-nitro-1H-indole-2-carboxylic acid
• IUPAC传统名: 7-nitro-1H-indole-2-carboxylic acid
• 别名: 7-Nitroindole-2carboxylic acid; NSC 69877; 7-Nitro-1H-indole-2-carboxylic acid

产品登记号

• EC号: 230-154-6
• MDL号: MFCD00044720
• CAS号: 6960-45-8

产品性质

• Empirical Formula (Hill Notation): C9H6N2O4
• 纯度: ≥98% (HPLC)
• 外观: powder
• 溶解度: DMSO: >20 mg/mL
• GHS警示词: Danger
• GHS危险声明: H319-H334
• 欧盟危险性物质标志: 刺激性(Irritant) (Xi)
• 个人保护装置: dust mask type N95 (US), Eyeshields, Faceshields, Gloves
• GHS警示性声明: P261-P305 + P351 + P338-P342 + P311
• 危险公开号: 36-43
• 安全公开号: 26-36/37
• 保存温度: room temp
• 德国WGK号: 3

产品详细信息

详细说明 (English)

Biochem/physiol Actions
CRT0044876 targets the apurinic endonuclease (APE1) active site and inhibits its 3′-phosphodiesterase and 3′-phosphatase activities-essential steps in excision repair-with minimal effects on endonuclease IV, BamH1 restriction endonuclease, or topoisomerase I even at concentrations as high as 100 μM. At non-cytotoxic concentrations, CRT0044876 potentiates the cytotoxicity of several DNA base-targeting compounds, with accumulation of apurinic sites.

详细说明 (简体中文)

Biochem/physiol Actions
CRT0044876 targets the apurinic endonuclease (APE1) active site and inhibits its 3′-phosphodiesterase and 3′-phosphatase activities-essential steps in excision repair-with minimal effects on endonuclease IV, BamH1 restriction endonuclease, or topoisomerase I even at concentrations as high as 100 μM. At non-cytotoxic concentrations, CRT0044876 potentiates the cytotoxicity of several DNA base-targeting compounds, with accumulation of apurinic sites.