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GW4064

产品号 G5172 公司名称 Sigma Aldrich
CAS号 278779-30-9 公司网站 http://www.sigmaaldrich.com
分子式 C28H22Cl3NO4 电 话 1-800-521-8956
分子量 542.83758 传 真
纯 度 ≥98% (HPLC) 电子邮件
保 存 desiccated Chembase数据库ID: 154436

产品价格信息

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产品别名

标题
GW4064
IUPAC标准名
3-[2-(2-chloro-4-{[3-(2,6-dichlorophenyl)-5-(propan-2-yl)-1,2-oxazol-4-yl]methoxy}phenyl)ethenyl]benzoic acid
IUPAC传统名
3-[2-(2-chloro-4-{[3-(2,6-dichlorophenyl)-5-isopropyl-1,2-oxazol-4-yl]methoxy}phenyl)ethenyl]benzoic acid
别名
3-(2,6-Dichlorophenyl)-4-(3’-carboxy-2-chlorostilben-4-yl)oxymethyl-5-isopropylisoxazole

产品登记号

MDL号 MFCD09971006
CAS号 278779-30-9

产品性质

Empirical Formula (Hill Notation) C28H22Cl3NO4
纯度 ≥98% (HPLC)
外观 white powder
溶解度 DMSO: >10 mg/mL
溶解度 H2O: insoluble
GHS危险品标识 GHS07
GHS警示词 Warning
GHS危险声明 H302-H319-H413
欧盟危险性物质标志 有害性(Harmful) 有害性(Harmful) (Xn)
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个人保护装置 dust mask type N95 (US), Eyeshields, Gloves
GHS警示性声明 P305 + P351 + P338
危险公开号 22-36
安全公开号 26
保存条件 desiccated
保存温度 2-8°C
德国WGK号 3

产品详细信息

详细说明 (English)
Biochem/physiol Actions
GW4064 is a FXR agonist. GW4064 is a potent (EC50 = 15 nM), non-steroidal agonist of the orphan nuclear receptor FXR. It shows no activity on other nuclear receptors including RAR up to 1 mM. This is an important tool for the study of the involvment of FXR in a variety of biological activities.
详细说明 (简体中文)
Biochem/physiol Actions
GW4064 is a FXR agonist. GW4064 is a potent (EC50 = 15 nM), non-steroidal agonist of the orphan nuclear receptor FXR. It shows no activity on other nuclear receptors including RAR up to 1 mM. This is an important tool for the study of the involvment of FXR in a variety of biological activities.

参考文献