cDPCP

• 产品号: C0996
• CAS号: 106343-54-8
• 分子式: C5H11Cl2N3Pt
• 分子量: 379.14494
• 纯 度: ≥98% (HPLC)

产品别名

• 标题: cDPCP
• IUPAC标准名: chloroplatinumylium pyridine diamine chloride
• IUPAC传统名: chloroplatinumylium pyridine diamine chloride
• 别名: cis-Diammine(pyridine)chloroplatinum(II) chloride; cis-[Pt(NH3)2(py)Cl]+ chloride; Pyriplatin

产品登记号

• CAS号: 106343-54-8
• MDL号: MFCD12912400

产品性质

• Empirical Formula (Hill Notation): C5H11Cl2N3Pt
• 纯度: ≥98% (HPLC)
• 外观: white to off-white solid
• 溶解度: H2O: >10 mg/mL
• GHS警示词: Danger
• GHS危险声明: H302-H315-H317-H319-H334-H335
• 欧盟危险性物质标志: 有害性(Harmful) (Xn)
• 个人保护装置: dust mask type N95 (US), Eyeshields, Faceshields, Gloves
• GHS警示性声明: P261-P280-P305 + P351 + P338-P342 + P311
• 危险公开号: 22-36/37/38-42/43
• 安全公开号: 26-36-45
• 保存温度: 2-8°C
• 德国WGK号: 1

产品详细信息

详细说明 (English)

Biochem/physiol Actions
cDPCP is a tumor cell permeable, potent platinum-based antineoplastic agent. It is a cationic monofunctional platinum(II) complex with unique chemical and biological properties. cDPCP binds covalently only to a single DNA base (the N7 atom of a single guanosine residue), and thus forms monofunctional rather than bifunctional lesions with DNA. cDPCP effectively blocks transcription from DNA templates carrying adducts of the complex, unlike DNA lesions of other monofunctional platinum(II) compounds.

详细说明 (简体中文)

Biochem/physiol Actions
cDPCP is a tumor cell permeable, potent platinum-based antineoplastic agent. It is a cationic monofunctional platinum(II) complex with unique chemical and biological properties. cDPCP binds covalently only to a single DNA base (the N7 atom of a single guanosine residue), and thus forms monofunctional rather than bifunctional lesions with DNA. cDPCP effectively blocks transcription from DNA templates carrying adducts of the complex, unlike DNA lesions of other monofunctional platinum(II) compounds.