ER-27319

• 产品号: E0656
• 分子式: C20H22N2O5
• 分子量: 370.39908
• 纯 度: ≥98% (HPLC)

产品别名

• 标题: ER-27319
• IUPAC标准名: 10-(3-aminopropyl)-3,4-dimethyl-9,10-dihydroacridin-9-one; oxalic acid
• IUPAC传统名: 10-(3-aminopropyl)-3,4-dimethylacridin-9-one; oxalic acid
• 别名: 10-(3-Aminopropyl)-3,4-dimethyl-9-acridone oxalate

产品登记号

• PubChem SID: 24724472
• MDL号: MFCD07784502

产品性质

• Empirical Formula (Hill Notation): C20H22N2O5
• 纯度: ≥98% (HPLC)
• 外观: solid
• 溶解度: DMSO: soluble28 mg/mL
• GHS警示词: Warning
• GHS危险声明: H302 + H312
• 欧盟危险性物质标志: 有害性(Harmful) (Xn)
• GHS警示性声明: P280
• 危险公开号: 21/22
• 安全公开号: 24/25
• 保存温度: 2-8°C
• 德国WGK号: 1

产品详细信息

详细说明 (English)

Biochem/physiol Actions
Selective Syk inhibitor. Induces tyrosine phosphorylation of Syk that has been demonstrated as critical for degranulation.
ER-27319 inhibits Syk activation with an IC50 = 10 μM. ER-27319 inhibits Syk by preventing the phosphorylated ITAM domain of FcεRI γ from activating Syk. ER-27319 does NOT inhibit previously activated Syk.1

详细说明 (简体中文)

Biochem/physiol Actions
Selective Syk inhibitor. Induces tyrosine phosphorylation of Syk that has been demonstrated as critical for degranulation.
ER-27319 inhibits Syk activation with an IC50 = 10 μM. ER-27319 inhibits Syk by preventing the phosphorylated ITAM domain of FcεRI γ from activating Syk. ER-27319 does NOT inhibit previously activated Syk.1