BVT.948

• 产品号: B6060
• CAS号: 39674-97-0
• 分子式: C14H11NO3
• 分子量: 241.24204
• 纯 度: ≥98% (HPLC)
• 保 存: desiccated

产品别名

• 标题: BVT.948
• IUPAC标准名: 4-hydroxy-3,3-dimethyl-2H,3H,5H-benzo[g]indole-2,5-dione
• IUPAC传统名: 4-hydroxy-3,3-dimethylbenzo[g]indole-2,5-dione
• 别名: 4-Hydroxy-3,3-dimethyl-2H-benzo[g]indole-2,5(3H)-dione

产品登记号

• MDL号: MFCD00616487
• CAS号: 39674-97-0
• PubChem SID: 24724422

产品性质

• Empirical Formula (Hill Notation): C14H11NO3
• 纯度: ≥98% (HPLC)
• 外观: red solid
• 溶解度: DMSO: soluble18 mg/mL
• 溶解度: H2O: insoluble
• GHS警示词: Warning
• GHS危险声明: H317
• 欧盟危险性物质标志: 刺激性(Irritant) (Xi)
• 个人保护装置: dust mask type N95 (US), Eyeshields, Faceshields, Gloves
• GHS警示性声明: P280
• 危险公开号: 43
• 安全公开号: 36/37
• 保存条件: desiccated
• 保存条件: protect from light
• 保存条件: under inert gas
• 德国WGK号: 3

产品详细信息

详细说明 (English)

Biochem/physiol Actions
BVT.948 is a non-competitive inhibitor of protein tyrosine phosphatase (PTP). Enhances insulin signaling in cells and inhibits several cytochrome P450 isoforms in vitro.
Features and Benefits
BVT.948 is a non-competitive inhibitor of protein tyrosine phosphatase (PTP). Enhances insulin signaling in cells and inhibits several cytochrome P450 isoforms in vitro. Works through a different mechanism then the other PTP inhibitors. BVT.948 was able to enhance insulin signaling in cells, although it did not increase tyrosine phosphorylation globally. Furthermore, the compound was active in vivo, enhancing insulin tolerance tests in ob/ob mice, therefore apparently enhancing insulin sensitivity. BVT.948 was able to inhibit several other PTPs tested and also was efficient at inhibiting several cytochrome P450 isoforms in vitro.

详细说明 (简体中文)

Biochem/physiol Actions
BVT.948 is a non-competitive inhibitor of protein tyrosine phosphatase (PTP). Enhances insulin signaling in cells and inhibits several cytochrome P450 isoforms in vitro.
Features and Benefits
BVT.948 is a non-competitive inhibitor of protein tyrosine phosphatase (PTP). Enhances insulin signaling in cells and inhibits several cytochrome P450 isoforms in vitro. Works through a different mechanism then the other PTP inhibitors. BVT.948 was able to enhance insulin signaling in cells, although it did not increase tyrosine phosphorylation globally. Furthermore, the compound was active in vivo, enhancing insulin tolerance tests in ob/ob mice, therefore apparently enhancing insulin sensitivity. BVT.948 was able to inhibit several other PTPs tested and also was efficient at inhibiting several cytochrome P450 isoforms in vitro.