Application Swainsonine is a potent inhibitor of various α-mannosidases, especially of α-mannosidase II.3 It inhibits glycoprotein processing4 and also acts as immune modulator.3,5 Swainsonine is an indolizidine alkaloid from the plant Metarrhizium anisopliae that is used as a potent α-mannosidase inhibitor1. Product S8195 has been used in chemical inhibition assays of CHO Lec2 cells to inhibit glycosylation 2. Biochem/physiol Actions Swainsonine is a potent α-mannosidase inhibitor. It also has antimetastatic, antiproliferative, and immunomodulatory activity 1. It also inhibits glycoprotein processing. Physical properties Soluble in water, methanol, DMSO |
Application Swainsonine is a potent inhibitor of various α-mannosidases, especially of α-mannosidase II.3 It inhibits glycoprotein processing4 and also acts as immune modulator.3,5 Swainsonine is an indolizidine alkaloid from the plant Metarrhizium anisopliae that is used as a potent α-mannosidase inhibitor1. Product S8195 has been used in chemical inhibition assays of CHO Lec2 cells to inhibit glycosylation 2. Biochem/physiol Actions Swainsonine is a potent α-mannosidase inhibitor. It also has antimetastatic, antiproliferative, and immunomodulatory activity 1. It also inhibits glycoprotein processing. Physical properties Soluble in water, methanol, DMSO |