PRIMA-1

• 产品号: P0069
• CAS号: 5608-24-2
• 分子式: C9H15NO3
• 分子量: 185.2203
• 纯 度: ≥98% (HPLC)

产品别名

• 标题: PRIMA-1
• IUPAC标准名: 2,2-bis(hydroxymethyl)-1-azabicyclo[2.2.2]octan-3-one
• IUPAC传统名: 2,2-bis(hydroxymethyl)-1-azabicyclo[2.2.2]octan-3-one
• 别名: 2,2-Bishydroxymethyl-1-aza-bicyclo[2.2.2]octan-3-one

产品登记号

• MDL号: MFCD04974196
• CAS号: 5608-24-2

产品性质

• Empirical Formula (Hill Notation): C9H15NO3
• 纯度: ≥98% (HPLC)
• 外观: white to off-white solid
• 溶解度: H2O: >10 mg/mL
• GHS警示词: Danger
• GHS危险声明: H302-H334
• 欧盟危险性物质标志: 有害性(Harmful) (Xn)
• 个人保护装置: dust mask type N95 (US), Eyeshields, Faceshields, Gloves
• GHS警示性声明: P261-P342 + P311
• 危险公开号: 22-43
• 安全公开号: 36/37
• 保存温度: 2-8°C
• 德国WGK号: 3

产品详细信息

详细说明 (English)

Biochem/physiol Actions
PRIMA-1 is a selective re-activator of mutant p53 activity in tumor cells, and an inducer of apoptosis and inhibitor of growth of human tumors with mutant p53. Mutations in the tumor suppressor p53 take place in >50% tumor cells. PRIMA-1 selectively restores sequence-specific DNA binding and transactivational activity to mutant p53 proteins at μM concentrations. PRIMA-1 works as a re-activator of the apoptotic function of mutant p53 via conformational modulation of function-specific epitopes.

详细说明 (简体中文)

Biochem/physiol Actions
PRIMA-1 is a selective re-activator of mutant p53 activity in tumor cells, and an inducer of apoptosis and inhibitor of growth of human tumors with mutant p53. Mutations in the tumor suppressor p53 take place in >50% tumor cells. PRIMA-1 selectively restores sequence-specific DNA binding and transactivational activity to mutant p53 proteins at μM concentrations. PRIMA-1 works as a re-activator of the apoptotic function of mutant p53 via conformational modulation of function-specific epitopes.