TDZD-8

• 产品号: T8325
• CAS号: 327036-89-5
• 分子式: C10H10N2O2S
• 分子量: 222.2636
• 纯 度: ≥98% (HPLC)
• 保 存: protect from light

产品别名

• 标题: TDZD-8
• IUPAC标准名: 4-benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione
• IUPAC传统名: 4-benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione
• 别名: 4-Benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione

产品登记号

• MDL号: MFCD04973552
• CAS号: 327036-89-5

产品性质

• 德国WGK号: 3
• GHS警示词: Danger
• GHS危险声明: H334
• 欧盟危险性物质标志: 刺激性(Irritant) (Xi)
• 个人保护装置: dust mask type N95 (US), Eyeshields, Faceshields, Gloves
• GHS警示性声明: P261-P342 + P311
• 危险公开号: 43
• 安全公开号: 36/37
• 保存条件: protect from light
• 保存温度: 2-8°C
• Empirical Formula (Hill Notation): C10H10N2O2S
• 纯度: ≥98% (HPLC)
• 外观: white needles
• 熔点: 63-64.4 °C
• 溶解度: DMSO: >10 mg/mL

产品详细信息

详细说明 (English)

Biochem/physiol Actions
TDZD-8 is a selective inhibitor of GSK-3, a thiadiazolidinone derivative, non-ATP competitive inhibitor of GSK-3β (IC50 = 2 μM). It does not inhibit Cdk-1/cyclin B, CK-II, PKA or PKC at >100 μM. TDZD-8 has been proposed to bind to the kinase site of GSK-3β.

详细说明 (简体中文)

Biochem/physiol Actions
TDZD-8 is a selective inhibitor of GSK-3, a thiadiazolidinone derivative, non-ATP competitive inhibitor of GSK-3β (IC50 = 2 μM). It does not inhibit Cdk-1/cyclin B, CK-II, PKA or PKC at >100 μM. TDZD-8 has been proposed to bind to the kinase site of GSK-3β.