Glp-Asn-Pro-d-Tyr-d-Trp-NH2

• 产品号: G5297
• CAS号: 882400-49-9
• 分子式: C34H40N8O8
• 分子量: 688.7302
• 纯 度: ≥98% (HPLC)

产品别名

• 标题: Glp-Asn-Pro-d-Tyr-d-Trp-NH2
• IUPAC标准名: (3S)-4-[(2S)-2-{[(1R)-1-{[(1R)-1-carbamoyl-2-(1H-indol-3-yl)ethyl]carbamoyl}-2-(4-hydroxyphenyl)ethyl]carbamoyl}pyrrolidin-1-yl]-4-oxo-3-{[(2S)-5-oxopyrrolidin-2-yl]formamido}butanamide
• IUPAC传统名: (3S)-4-[(2S)-2-{[(1R)-1-{[(1R)-1-carbamoyl-2-(1H-indol-3-yl)ethyl]carbamoyl}-2-(4-hydroxyphenyl)ethyl]carbamoyl}pyrrolidin-1-yl]-4-oxo-3-{[(2S)-5-oxopyrrolidin-2-yl]formamido}butanamide
• 别名: JAK4D

产品登记号

• MDL号: MFCD11114385
• CAS号: 882400-49-9

产品性质

• Empirical Formula (Hill Notation): C34H40N8O8
• 纯度: ≥98% (HPLC)
• 相关基因信息: rat ... TRH(7200), TRHDE(29953), TRHR(7201)
• 外观: white solid
• 溶解度: H2O: >2 mg/mL
• 个人保护装置: Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
• 保存温度: -20°C
• 德国WGK号: 2

产品详细信息

详细说明 (English)

Amino Acid Sequence
Glp-Asn-Pro-Tyr-Trp-NH2
Biochem/physiol Actions
The synthetic peptide Glp-Asn-Pro-d-Tyr-d-Trp-NH2 mimics and amplifies central actions of TRH in rat without releasing TSH. Glp-Asn-Pro-d-Tyr-d-Trp-NH2 has dual pharmacological activities: it inhibits TRH-DE and binds to central TRH receptors with nM affinity in rat hippocampus and cortex but not pituitary or heterologous cells expressing TRH receptor 1 (TRHR1) or TRH receptor 2 (TRHR2). The peptide can be a potent tool for probing the role of TRH actions in the CNS and a platform for development of novel TRH-based therapeutics for neuro diseases.

详细说明 (简体中文)

Amino Acid Sequence
Glp-Asn-Pro-Tyr-Trp-NH2
Biochem/physiol Actions
The synthetic peptide Glp-Asn-Pro-d-Tyr-d-Trp-NH2 mimics and amplifies central actions of TRH in rat without releasing TSH. Glp-Asn-Pro-d-Tyr-d-Trp-NH2 has dual pharmacological activities: it inhibits TRH-DE and binds to central TRH receptors with nM affinity in rat hippocampus and cortex but not pituitary or heterologous cells expressing TRH receptor 1 (TRHR1) or TRH receptor 2 (TRHR2). The peptide can be a potent tool for probing the role of TRH actions in the CNS and a platform for development of novel TRH-based therapeutics for neuro diseases.